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DTI OF POST-ICTAL CHANGES IN PATIENTS WITH TEMPORAL LOBE EPILEPSY

DTI OF POST-ICTAL CHANGES IN PATIENTS WITH TEMPORAL LOBE EPILEPSY
颞叶癫痫患者发作后变化的 DTI
批准号:
7601875
负责人:
Alyssa Ann Brewer
金额:
$0.58万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-06-01 至 2008-05-31

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. INTRODUCTION: Behavioral observations show that epileptic seizures have significant short term functional consequences lasting up to 24 hours following the seizure itself. Many epileptic patients suffer from a post-ictal paresis that lasts for several hours, and occasionally for a day or more. It is thought that this post-ictal state correlates with cellular changes such as edema. Thus measurements using diffusion tensor imaging (DTI) during the post-ictal period may reveal specific differences in diffusivity, which could be used to aid in the localization of seizure foci. In addition, long-term, intractable epilepsy causes neuronal death and eventual sclerosis. Since DTI can measure changes produced by such sclerotic lesions, a comparison of the changes in the fiber tracts in patients with long-term epilepsy with those of normal controls may aid in our understanding of how intractable seizures alter normal cortical organization. METHODS: We are using whole brain DTI to make measurements of white matter tract changes in epileptic patients. In this study, we have two specific aims: (1) to use DTI to measure post-ictal changes in diffusivity in focal temporal lobe epilepsy (TLE) and (2) to compare the inter-ictal DTI measurements of white matter fiber tracts in patients with long-term TLE with those of normal subjects. CONCLUSIONThis work has the potential for both clinical and biological impact. Identifying seizure loci more effectively using non-invasive methods would be a significant contribution to the treatment of epilepsy by providing both more accurate target regions for resection as well as quantitative metrics for assessing the degree of white matter deterioration. In addition, successful modeling and localization of neural pathway structures should motivate a parallel basic science effort to clarify the cellular basis of the macroscopic signals measured using DTI.
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SEVERAL VISUAL FIELD MAPS WITH DIFFERENTIAL STIMULUS SELECTIVITY
  • 批准号:
    7358751
  • 项目类别:
  • 资助金额:
    $0.33万
  • 财政年份:
    2006
  • 负责人:
    Alyssa Ann Brewer
  • 依托单位:
DTI OF POST-ICTAL CHANGES IN PATIENTS WITH TEMPORAL LOBE EPILEPSY
  • 批准号:
    7358835
  • 项目类别:
  • 资助金额:
    $0.31万
  • 财政年份:
    2006
  • 负责人:
    Alyssa Ann Brewer
  • 依托单位:
NEW HUMAN VO CLUSTER SUBDIVISIONS DERIVED FROM VISUAL FIELD MAPPING
  • 批准号:
    7358828
  • 项目类别:
  • 资助金额:
    $0.31万
  • 财政年份:
    2006
  • 负责人:
    Alyssa Ann Brewer
  • 依托单位:
VISUAL FIELD MAPS IN HUMAN VENTRAL OCCIPITOTEMPORAL
  • 批准号:
    6978407
  • 项目类别:
  • 资助金额:
    $0.5万
  • 财政年份:
    2004
  • 负责人:
    Alyssa Ann Brewer
  • 依托单位:
海外基金