FERROUS AND FERRIC ION CONTAINING MODEL SYSTEMS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 亚铁和铁离子在许多生物体系中扮演着重要的角色，通过Fenton化学催化产生自由基。高场ESR，由于其优越的取向分辨率和对在较低频率下没有ESR的离子的敏感性，可以提供对铁和亚铁离子的配体结构的洞察，从而有助于阐明这些体系的功能。为了获得研究这些非均相体系所需的专业知识，我们一直在研究单晶中含有亚铁和铁离子的模型化合物。一般来说，铁和铁系统中的线宽是相当宽的，只有在液氦温度下才容易观察到。然而，我们已经获得了铁和铁系统的良好分辨率的单晶光谱，我们正在开发技术来研究更直接的生物意义的系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ferrous and ferric ions play key roles in many biological systems for the catalytic generation of free radicals through Fenton chemistry. High field ESR, due to its superior orientational resolution and sensitivity to ions that are otherwise ESR silent at lower frequencies, can offer insights into the ligand structure of ferric and ferrous ions and thus inform the elucidation of function of these systems. In order to gain the necessary expertise for studying these heterogeneous systems, we have been studying model compounds, in single crystals, that contain ferrous and ferric ions. The linewidths in ferrous and ferric systems are, generally speaking, quite broad and only readily observable at liquid helium temperatures. Nevertheless, we have obtained well-resolved single crystal spectra on both ferrous and ferric systems and we are developing the technology for studying systems of more direct biological significance.