Elucidating the roles and mechanisms of activation of NLRP3 inflammasomes and developing therapeutic interventions for severe steroid-resistant asthma

严重的哮喘是一个主要的临床问题。没有有效的治疗方法，因为我们不知道它是如何发生的。我们已经确定了一种被称为“炎症体”的因素，我们认为它会导致严重的哮喘。我们已经生产了一种新的这种因子的抑制剂，并在实验中表明，它可能会抑制严重哮喘的重要症状。我们现在的目标是准确地找出这种炎症体是如何导致严重哮喘的，并使我们的新抑制剂朝着治疗开发的方向发展。

Severe asthma is a major clinical issue. There are no effective treatments because we don’t understand how it occurs. We have identified a factor called an “inflammasome” that we think causes severe asthma. We have produced a new inhibitor of this factor, and shown experimentally that it may suppress important symptoms of severe asthma. We now aim to work out precisely how this inflammasome causes severe asthma and progress our new inhibitor towards therapeutic development.