Nutrition, Stress and Bone in Older Puerto Ricans

描述(申请人提供)：居住在美国本土的波多黎各老年人已被确定为患有过度慢性病的高风险群体。虽然波多黎各人显然患有几种慢性健康疾病，但人们对骨质疏松症这一美国主要公共健康威胁是如何影响这一人群的了解要少得多。我们建议将我们的工作扩展到目前正在进行的1,200名波多黎各成年人的队列中，他们的基线年龄为50-75岁，他们参加了波士顿波多黎各人口健康和健康差距中心[NIA补助金编号5P01AG023394-02]。因为这个队列已经收集了相当多的数据，在这项研究中增加与骨骼相关的测量将提供一种非常有效的方式来检验关于营养和骨密度的其他假设。我们的目标是1)评估一组年龄在52-77岁的波士顿波多黎各成年人的骨密度状况；2)检查饮食因素与髋部、脊柱和全身的BMD和骨转换标志物之间的关系；3)检查应激和炎症与髋部、脊柱、脚跟和全身的BMD和骨转换标志物之间的关系；以及4)检查饮食因素如何调节候选基因和骨健康指标之间的关联，包括髋部、脊柱和全身的BMD和骨转换标志物。这个拟议的项目实现了新的NIH路线图中确定的使命，即通过发现疾病和残疾的预防、检测、诊断和治疗方面的新知识来改善国家的健康状况，最终目标是减少和消除种族和少数民族之间的健康差距。

DESCRIPTION (provided by applicant): Puerto Rican older adults living in the U.S. mainland have been identified as a group highly at-risk of excess chronic conditions. While it is clear that Puerto Ricans suffer from several chronic health conditions, much less is known about how osteoporosis, a major public health threat in the U.S., affects this population. We propose to extend our work in the currently ongoing cohort of 1,200 Puerto Rican adults, aged 50-75 y at baseline, who are participating in the Boston Puerto Rican Center on Population Health and Health Disparities [NIA Grant No. 5P01AG023394-02]. Because considerable amounts of data are already being collected with this cohort, the addition of bone related measurements to this study will provide a highly efficient way to examine additional hypotheses on nutrition and bone mineral density. We aim to 1) assess the status of bone mineral density in a group of Boston Puerto Rican adults, aged 52-77 y; 2) examine associations between dietary factors and BMD of the hip, spine, and total body and markers of bone turnover; 3) examine associations between stress and inflammation and BMD of the hip, spine, heel, and total body and markers of bone turnover; and 4)examine how dietary factors modulate the association between candidate genes and measures of bone health including BMD of the hip, spine, and total body and markers of bone turnover. This proposed project addresses the mission defined in the new NIH roadmap, to improve the nation's health by uncovering new knowledge in the prevention, detection, diagnosis, and treatment of disease and disability, with the ultimate goal of reducing and eliminating health disparities among racial and ethnic minorities.