Nutrition, Stress and Bone in Older Puerto Ricans

描述（由申请人提供）：居住在美国大陆的波多黎各老年人已被确定为过度慢性疾病的高风险群体。虽然很明显，波多黎各人患有几种慢性健康状况，但对骨质疏松症，美国的一个主要公共健康威胁，影响着这个群体。我们建议在目前正在进行的1，200名波多黎各成年人队列中扩展我们的工作，基线年龄为50-75岁，他们正在参加波士顿波多黎各人口健康和健康差异中心[NIA批准号5 P01 AG 023394 -02]。由于该队列已经收集了大量数据，因此在本研究中增加骨相关测量将为检查营养和骨矿物质密度的其他假设提供一种高效的方法。我们的目的是：1）评估一组年龄在52-77岁的波士顿波多黎各成年人的骨矿物质密度状况; 2）检查饮食因素与髋部、脊柱和全身BMD以及骨转换标志物之间的关联; 3）检查应激和炎症与髋部、脊柱、足跟和全身BMD以及骨转换标志物之间的关联;以及4）检查饮食因素如何调节候选基因与骨健康测量（包括髋部、脊柱和全身的BMD以及骨转换标记物）之间的关联。这个拟议的项目解决了新的NIH路线图中定义的使命，通过发现预防，检测，诊断和治疗疾病和残疾的新知识来改善国家的健康，最终目标是减少和消除种族和少数民族之间的健康差距。

DESCRIPTION (provided by applicant): Puerto Rican older adults living in the U.S. mainland have been identified as a group highly at-risk of excess chronic conditions. While it is clear that Puerto Ricans suffer from several chronic health conditions, much less is known about how osteoporosis, a major public health threat in the U.S., affects this population. We propose to extend our work in the currently ongoing cohort of 1,200 Puerto Rican adults, aged 50-75 y at baseline, who are participating in the Boston Puerto Rican Center on Population Health and Health Disparities [NIA Grant No. 5P01AG023394-02]. Because considerable amounts of data are already being collected with this cohort, the addition of bone related measurements to this study will provide a highly efficient way to examine additional hypotheses on nutrition and bone mineral density. We aim to 1) assess the status of bone mineral density in a group of Boston Puerto Rican adults, aged 52-77 y; 2) examine associations between dietary factors and BMD of the hip, spine, and total body and markers of bone turnover; 3) examine associations between stress and inflammation and BMD of the hip, spine, heel, and total body and markers of bone turnover; and 4)examine how dietary factors modulate the association between candidate genes and measures of bone health including BMD of the hip, spine, and total body and markers of bone turnover. This proposed project addresses the mission defined in the new NIH roadmap, to improve the nation's health by uncovering new knowledge in the prevention, detection, diagnosis, and treatment of disease and disability, with the ultimate goal of reducing and eliminating health disparities among racial and ethnic minorities.