Bone microarchitecture, diabetes and change in bone mineral density in Puerto Rican adults

波多黎各成年人的骨微结构、糖尿病和骨矿物质密度变化

• 批准号: 10242625
• 负责人: Katherine L Tucker
• 金额: $ 53.89万
• 依托单位: UNIVERSITY OF MASSACHUSETTS LOWELL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-03 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242625
• 关键词: Address; Adult; Advanced Glycosylation End Products; Affect; Age; Animals; Antioxidants; Black Populations; Blood specimen; Bone Density; Boston; Caribbean Hispanic; Caribbean region; Complex; Data; Defect; Development; Diabetes Mellitus; Dual-Energy X-Ray Absorptiometry; Early Diagnosis; Elderly; Fasting; Fracture; Future; High Prevalence; Hip region structure; Hispanic; Hispanic Populations; Human; Image; Incidence; Individual; Insulin Resistance; Intake; Intervention; Link; Longitudinal Studies; Longitudinal cohort study; Measurement; Measures; Mediating; Mediator of activation protein; Methods; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Osteoporosis; Participant; Plasma; Population; Population Group; Porosity; Prevalence; Public Health; Publishing; Puerto Rican; Quality of life; Questionnaires; Research; Risk; Risk Factors; Scanning; Serum; Skin; Testing; Time; Trabecular Bone Score; Underserved Population; Vertebral column; Vitamin B6; Work; aged; bone; bone health; bone loss; bone mass; bone quality; bone strength; dietary; disability; fracture risk; fragility fracture; health disparity; high risk; high risk population; hip bone; improved; innovation; inorganic phosphate; mechanical properties; men; negative affect; novel; osteoporosis with pathological fracture; pentosidine; prevent; therapy development; tool

PROJECT SUMMARY Recent national data indicate a higher prevalence of osteoporosis (OP) among Hispanics, compared with non- Hispanic whites or blacks. As one of the fastest growing segments of the U.S. population, this group is projected to have the largest increase in OP-related fracture from 2005 to 2025. Hispanic adults of Caribbean origin have been shown to have poorer bone quality than non-Hispanic whites. Puerto Ricans, in particular, have higher prevalence of OP than previously appreciated. Although higher bone mineral density (BMD) has been noted in those with type 2 diabetes (T2D), T2D contributes to compromised bone strength, cortical defects and increased cortical porosity increasing risk of fracture. This is of particular concern for Puerto Ricans who have a high prevalence of T2D. One mechanism for poor bone quality among those with T2D is the accumulation of advanced glycation end-products (AGE), which affect bone mechanical properties. Animal studies suggest that antioxidant activity from vitamin B6 may inhibit AGE formation. Greater plasma pyridoxyl- 5'-phosphate (PLP, vitamin B6) concentration and intake of vitamin B6 has been associated with less bone loss over time and reduced risk of fracture; but mechanisms are unclear. Trabecular bone score (TBS), a novel measure of trabecular microarchitecture of the lumbar spine, is indicative of fragility fracture risk, even among those with normal BMD; however, research on TBS for assessing bone quality is limited and urgently needed. Further, assessment of bone strength by novel micro-indentation may elucidate differences in bone quality among T2D at risk for OP. Therefore, our central hypothesis is that Puerto Rican adults with T2D will have poor bone strength (micro-indentation), and greater loss of TBS at the spine and of BMD at the spine and hip compared to individuals without T2D; and that this will be moderated by high plasma AGE concentration. Our secondary hypothesis is that greater plasma PLP will be associated with lower plasma AGE and therefore higher bone strength (micro-indentation), and less loss of TBS and BMD over time. All available 860 Puerto Rican adults who participated in the Boston Puerto Rican Osteoporosis Study with valid BMD data will be invited to participate in the proposed study. Participants will complete a questionnaire, a repeat DXA scan, undergo bone micro-indentation, skin autofluorescence measurement of AGES and provide a fasting blood sample. The proposed research is innovative in the inclusion of TBS as a measure of bone quality, micro- indentation to evaluate bone strength, the examination of AGE as an effect modifier linking diabetes and bone health, and the consideration of PLP as a factor in AGE in a longitudinal study. This work is urgently needed to improve our understanding of complex risk factors for bone health, and to provide important information for the development of future interventions to prevent bone loss and fracture risk, particularly in high-risk populations with health disparities.

项目概要 最近的国家数据表明，与非西班牙裔美国人相比，西班牙裔美国人骨质疏松症 (OP) 的患病率更高 西班牙裔白人或黑人。作为美国人口增长最快的群体之一，该群体 预计从 2005 年到 2025 年，OP 相关骨折的增幅最大。 加勒比地区的西班牙裔成年人 研究表明，原住民的骨骼质量比非西班牙裔白人较差。尤其是波多黎各人， OP 的患病率比之前估计的要高。尽管骨矿物质密度（BMD）较高 在 2 型糖尿病 (T2D) 患者中，T2D 会导致骨强度、皮质功能受损 缺陷和增加的皮质孔隙度增加了骨折的风险。这是波多黎各特别关注的问题 T2D 患病率较高的黎加人。 T2D 患者骨质量差的一种机制是 晚期糖基化终产物（AGE）的积累，影响骨的机械性能。动物 研究表明，维生素 B6 的抗氧化活性可能会抑制 AGE 的形成。更大的血浆吡啶酚- 5'-磷酸盐（PLP、维生素 B6）浓度和维生素 B6 的摄入量与骨质减少有关 随着时间的推移而损失并降低骨折风险；但机制尚不清楚。骨小梁评分 (TBS) 腰椎小梁微结构的测量表明脆性骨折风险，即使在 骨密度正常者；然而，用于评估骨质量的 TBS 研究有限且迫切需要。 此外，通过新型微压痕评估骨强度可以阐明骨质量的差异 存在 OP 风险的 T2D 患者。因此，我们的中心假设是患有 T2D 的波多黎各成年人将患有 骨强度差（微压痕），脊柱 TBS 以及脊柱和髋部 BMD 损失更大 与没有 T2D 的个体相比；并且这将通过高血浆 AGE 浓度来缓解。我们的 第二个假设是血浆 PLP 越高，血浆 AGE 越低，因此 随着时间的推移，骨强度更高（微压痕），TBS 和 BMD 损失更少。全部可用 860 波多黎各 参加波士顿波多黎各骨质疏松症研究并拥有有效 BMD 数据的黎各成年人将 受邀参加拟议的研究。参与者将完成一份调查问卷、重复 DXA 扫描、 进行骨微压痕、皮肤自发荧光AGES测量并提供空腹血 样本。拟议的研究具有创新性，将 TBS 作为骨质量、微骨质量的衡量标准。 压痕评估骨强度，检查 AGE 作为糖尿病与骨之间的影响调节剂 健康状况，以及在纵向研究中将 PLP 视为 AGE 的一个因素。这项工作迫切需要 提高我们对骨骼健康复杂风险因素的理解，并为骨骼健康提供重要信息 制定未来的干预措施以预防骨质流失和骨折风险，特别是在高危人群中 与健康差异。

项目成果

Specific Dietary Protein Sources Are Associated with Cardiometabolic Risk Factors in the Boston Puerto Rican Health Study.

• DOI: 10.1016/j.jand.2021.05.020
• 发表时间: 2022-03
• 期刊: Journal of the Academy of Nutrition and Dietetics
• 影响因子: 4.8
• 作者: Riseberg E;Lopez-Cepero A;Mangano KM;Tucker KL;Mattei J
• 通讯作者: Mattei J

Diet-derived fruit and vegetable metabolites show sex-specific inverse relationships to osteoporosis status.

饮食来源的水果和蔬菜代谢物表现出与骨质疏松状况的性别特异性逆关系。

• DOI: 10.1016/j.bone.2020.115780
• 发表时间: 2021-03
• 期刊: Bone
• 影响因子: 4.1
• 作者: Mangano KM;Noel SE;Lai CQ;Christensen JJ;Ordovas JM;Dawson-Hughes B;Tucker KL;Parnell LD
• 通讯作者: Parnell LD

Patterns of change in cardiovascular risk assessments and ankle brachial index among Puerto Rican adults.

• DOI: 10.1371/journal.pone.0245236
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Noel SE;Cornell DJ;Zhang X;Mirochnick JC;Mattei J;Falcón LM;Tucker KL
• 通讯作者: Tucker KL

Sufficient Plasma Vitamin C Is Related to Greater Bone Mineral Density among Postmenopausal Women from the Boston Puerto Rican Health Study.

波士顿波多黎各健康研究表明，充足的血浆维生素 C 与绝经后妇女较高的骨矿物质密度有关。

• DOI: 10.1093/jn/nxab291
• 发表时间: 2021
• 期刊: The Journal of nutrition
• 作者: Mangano,KelseyM;Noel,SabrinaE;Dawson-Hughes,Bess;Tucker,KatherineL
• 通讯作者: Tucker,KatherineL