CORONARY ARTERY CALCIFICATION IN TYPE I DIABETES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 冠心病(CAD)是I型糖尿病患者死亡的主要原因。冠心病也发生在生命的早期，影响女性的频率与男性一样高，相关的死亡率显著高于普通人群。这项研究将集中在I型糖尿病高危人群中非侵入性检测冠心病，以便在未来的筛查和预防计划中应用。将从丹佛大都市区招募800名I型糖尿病患者和600名非糖尿病对照组的样本。人口分布与全国和丹佛地区I型糖尿病的人口统计数字相近。这项研究将招募大约49%的男性和51%的女性受试者；预期的种族分布是87%的白人，7%的西班牙裔，3%的黑人和3%的其他人。要参加这项研究，所有受试者的年龄必须在20岁到55岁之间。I型糖尿病患者必须患有糖尿病至少10年，必须在30岁之前确诊，并且必须在确诊后一年内服用胰岛素。糖尿病患者和非糖尿病患者都将前来就诊。在这次访问中，患者将被问及他们的医学背景。将测量体重、身高、腰围、臀围和血压。还将获得心电图、尿样和血样。糖尿病患者将被要求在3年内再来一次诊所就诊。患者还将接受电子束计算机断层扫描(EBCT)，这将寻找心脏中的冠状动脉钙化。同时将进行腹部扫描，以测量腹部的脂肪量。计算冠状动脉钙化(CAC)积分和左心室面积(LV Area)。CAC和较大的LV面积可能是冠心病的早期征象。所有患者将被要求在3年内重复进行EBCT。在一项子研究中，50名高风险糖尿病患者(CAC评分约为100分)、30名低风险糖尿病患者(CAC评分低于100分)和20名对照组将接受额外的访问。这次访问将包括休息/压力测试，该测试观察休息和最大限度运动期间的心脏血流(使用跑步机)。在这两种情况下，都将使用造影剂来确定心脏中的血流。糖尿病患者将被要求在3年内重复休息/压力测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Coronary artery disease (CAD) is the main cause of death in person with Type I diabetes. CAD also occurs earlier in life, affects women as often as men, and associated mortality is dramatically higher than that in the general population. This study will focus on non-invasive detection of CAD in high-risk persons with Type I diabetes for application in future screening and prevention programs. A sample of 800 patients with Type I diabetes and 600 non-diabetic controls will be recruited from the Denver Metro Area. The population distribution approximates the national and Denver area demographics for Type I diabetes. This study will recruit approximately 49% male and 51% female subjects; the expected ethnic distribution is 87% white, 7% Hispanic, 3% black, and 3% other. To enroll in the study, all subjects must be between 20 and 55 years of age. Patients with type I diabetes must have had diabetes for at least 10 years, must have been diagnosed before the age of 30, and must have had insulin within one year of being diagnosed. Both diabetic and non-diabetic patients will come for an initial clinic visit. At this visit, patients will be asked about their medical background. Measurements of weight, height, waist and hip circumference, and blood pressure will be taken. An electrocardiogram (ECG), a urine sample and blood sample will also be obtained. Diabetic patients will be asked to come in for another clinic visit in 3-years. Patients will also be scheduled for an electron-beam computed tomography scan (EBCT), which will look for coronary artery calcification in the heart. A scan of the abdomen will be done at the same time to measure the amount of fat in the abdomen. A coronary artery calcification (CAC) score and left ventricular area (LV area) will be calculated. CAC and large LV area may be early signs of CAD. All patients will be asked to have a repeat EBCT in 3 years. In a substudy, 50 high-risk diabetics (CAC score about 100), 30 low-risk diabetics (CAC score below 100), and 20 controls will come in for an additional visit. This visit will consist of a rest/stress test, which looks at heart blood flow at rest and during maximal exercise (using a treadmill). A contrast dye will be used in both cases to determine the blood flow in the heart. Patients with diabetes will be asked to repeat the rest/stress test in 3-years.