CORONARY ARTERY CALCIFICATION IN TYPE I DIABETES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 冠状动脉疾病（CAD）是I型糖尿病患者死亡的主要原因。 CAD也发生在生命早期，影响女性和男性一样频繁，相关死亡率显著高于一般人群。 本研究将重点关注I型糖尿病高危人群中CAD的非侵入性检测，以应用于未来的筛查和预防计划。 将从丹佛都会区招募800名I型糖尿病患者和600名非糖尿病对照者。 人口分布接近I型糖尿病的国家和丹佛地区人口统计学。本研究将招募约49%的男性和51%的女性受试者;预期种族分布为87%的白色、7%的西班牙裔、3%的黑人和3%的其他。 所有受试者的年龄必须在20 - 55岁之间，方可入组本研究。 I型糖尿病患者必须患有糖尿病至少10年，必须在30岁之前被诊断出来，并且必须在诊断后一年内接受胰岛素治疗。 糖尿病和非糖尿病患者都将接受首次门诊访视。 在这次访问中，患者将被问及他们的医学背景。 将测量体重、身高、腰围和臀围以及血压。 还将采集心电图（ECG）、尿样和血样。 糖尿病患者将被要求在3年内再次就诊。 患者还将安排电子束计算机断层扫描（EBCT），这将寻找心脏冠状动脉钙化。 同时进行腹部扫描，以测量腹部的脂肪量。 将计算冠状动脉钙化（CAC）评分和左心室面积（LV面积）。 CAC和大的LV面积可能是CAD的早期迹象。 所有患者将被要求在3年内重复EBCT。 在一项子研究中，50名高危糖尿病患者（CAC评分约为100），30名低危糖尿病患者（CAC评分低于100）和20名对照者将接受额外的访视。 此次访视将包括静息/应激试验，观察静息和最大运动（使用跑步机）期间的心脏血流量。 在这两种情况下，将使用造影剂来确定心脏中的血流量。 糖尿病患者将被要求在3年内重复休息/压力测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Coronary artery disease (CAD) is the main cause of death in person with Type I diabetes. CAD also occurs earlier in life, affects women as often as men, and associated mortality is dramatically higher than that in the general population. This study will focus on non-invasive detection of CAD in high-risk persons with Type I diabetes for application in future screening and prevention programs. A sample of 800 patients with Type I diabetes and 600 non-diabetic controls will be recruited from the Denver Metro Area. The population distribution approximates the national and Denver area demographics for Type I diabetes. This study will recruit approximately 49% male and 51% female subjects; the expected ethnic distribution is 87% white, 7% Hispanic, 3% black, and 3% other. To enroll in the study, all subjects must be between 20 and 55 years of age. Patients with type I diabetes must have had diabetes for at least 10 years, must have been diagnosed before the age of 30, and must have had insulin within one year of being diagnosed. Both diabetic and non-diabetic patients will come for an initial clinic visit. At this visit, patients will be asked about their medical background. Measurements of weight, height, waist and hip circumference, and blood pressure will be taken. An electrocardiogram (ECG), a urine sample and blood sample will also be obtained. Diabetic patients will be asked to come in for another clinic visit in 3-years. Patients will also be scheduled for an electron-beam computed tomography scan (EBCT), which will look for coronary artery calcification in the heart. A scan of the abdomen will be done at the same time to measure the amount of fat in the abdomen. A coronary artery calcification (CAC) score and left ventricular area (LV area) will be calculated. CAC and large LV area may be early signs of CAD. All patients will be asked to have a repeat EBCT in 3 years. In a substudy, 50 high-risk diabetics (CAC score about 100), 30 low-risk diabetics (CAC score below 100), and 20 controls will come in for an additional visit. This visit will consist of a rest/stress test, which looks at heart blood flow at rest and during maximal exercise (using a treadmill). A contrast dye will be used in both cases to determine the blood flow in the heart. Patients with diabetes will be asked to repeat the rest/stress test in 3-years.