Clinical Resource Core

临床资源核心

• 批准号: 10646146
• 负责人: MARIAN J REWERS
• 金额: $ 14.23万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646146
• 关键词: Acceleration; Adolescent; Adult; Age; Area; Autoantibodies; Autoimmunity; Basic Science; Beta Cell; Bioinformatics; Biological; Biological Assay; Biostatistical Methods; Blood specimen; Cardiovascular Diseases; Cells; Center for Translational Science Activities; Child; Childhood diabetes; Clinic; Clinical; Clinical Data; Clinical Research; Collaborations; Colorado; Communication; Complications of Diabetes Mellitus; Computerized Medical Record; Core Facility; Data; Data Management Resources; Databases; Development; Diabetes Mellitus; Diabetic Nephropathy; Diagnostic; Disease; Economic Burden; Equipment; Faculty; Faculty Recruitment; Fostering; Functional disorder; Funding; Gestational Diabetes; Goals; Grant; Growth; Health; Hospitals; Human Resources; Hyperglycemia; Improve Access; Incidence; Individual; Infant; Infrastructure; Institution; Insulin Resistance; Insulin-Dependent Diabetes Mellitus; Laboratories; Longevity; Longitudinal Studies; Medical; Medical center; Mentored Clinical Scientist Development Program; Metabolic dysfunction; Molecular Analysis; Morbidity - disease rate; Mothers; Non-Insulin-Dependent Diabetes Mellitus; Outcome; Participant; Patient Recruitments; Patients; Pediatric Hospitals; Persons; Phenotype; Physicians; Plasma; Population; Process; Productivity; Protocols documentation; Registries; Research; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Sampling; Scientist; Serum; Services; Statistical Data Interpretation; Talents; Teacher Professional Development; Techniques; Technology; Testing; Tissue Banks; Tissue Sample; Training; Translational Research; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; analytical tool; bench-to-bedside translation; biobank; clinical care; clinical center; clinical translation; cystic fibrosis related diabetes; data warehouse; diabetes control; diabetes risk; diabetic; eligible participant; genetic analysis; human leukocyte antigen testing; improved; interest; metabolic phenotype; mortality; non-diabetic; patient registry; peripheral blood; prevent; programs; recruit; repository; research facility; sample collection; segregation; skills; type I and type II diabetes

CLINICAL RESOURCE CORE PROGRAM SUMMARY/ABSTRACT Diabetes represents a worldwide health crisis, with the incidence of both type 1 diabetes (T1D) and type 2 diabetes (T2D) steadily increasing. While autoimmunity is central to T1D, many key aspects of the disease process are shared by T1D and T2D, including beta cell dysfunction, hyperglycemia, metabolic dysfunction and insulin resistance. Complications of T1D and T2D also have many similarities, including cardiovascular disease (CVD) and diabetic kidney disease (DKD), both leading causes of morbidity and mortality. The University of Colorado Anschutz Medical Center (UC AMC) is among world leaders in clinical translational investigations into T1D and T2D across the lifespan, as well as in gestational diabetes (GDM) and cystic fibrosis-related diabetes (CFRD). Funding through the Diabetes Research Center (DRC) would capitalize on these existing strengths and catalyze the formation of an integrated comprehensive diabetes research program. The Clinical Resource Core (CR) of the UC Denver DRC stands at the interface of multiple institutions, programs and individuals, all of whom are working to prevent or ameliorate the devastating long term complications of diabetes and its high economic burden. The CR core would leverage the current clinical research facilities and equipment available at the Barbara Davis Center for Childhood Diabetes (BDC), UC AMC’s Clinical Translational Research Center (CTRC), The University of Colorado Hospital, Denver Veteran’s Administration Medical Center (VA) and Children’s Hospital Colorado. The DRC CR core would integrate diabetes research across these institutions through communication and distribution of the resources available, and create shared sample and data biobanks and a recruiting database of mothers, infants, children, adolescents and adults with diabetes, diabetes risk and controls. Such integration would accelerate progress and increase the quality of diabetes research, coalesce existing strengths and strategically focus faculty recruitment in areas of needed growth. DRC funding would also attract new talent at postgraduate and junior faculty levels and add unique components of infrastructure needed for discovery. Specifically, we will improve access and collaborations for recruiting subjects, tracking data and banking tissue samples from well-phenotyped participants with diabetes and control subjects across the lifespan; establish collections of samples from our well-characterized subjects and facilitate the ability of DRC users to perform assays from peripheral blood, serum and plasma utilizing state of the art techniques; improve provision of specialized diagnostic and analytic services.

临床资源核心 项目概要/摘要 糖尿病是一场全球性的健康危机，1 型糖尿病 (T1D) 和 2 型糖尿病的发病率都很高 糖尿病（T2D）稳步增加。虽然自身免疫是 T1D 的核心，但该疾病的许多关键方面 T1D 和 T2D 共有的过程，包括 β 细胞功能障碍、高血糖、代谢功能障碍和 胰岛素抵抗。 T1D 和 T2D 的并发症也有许多相似之处，包括心血管疾病 （CVD）和糖尿病肾病（DKD），两者都是发病和死亡的主要原因。大学 科罗拉多安舒茨医疗中心 (UC AMC) 在临床转化研究方面处于世界领先地位 整个生命周期中的 T1D 和 T2D，以及妊娠糖尿病 (GDM) 和囊性纤维化相关糖尿病 （CFRD）。通过糖尿病研究中心（DRC）提供的资金将利用这些现有的 优势并促进综合全面的糖尿病研究计划的形成。 加州大学丹佛分校 DRC 的临床资源核心 (CR) 处于多个机构、项目的接口处 和个人，所有人都在努力预防或改善破坏性的长期并发症 糖尿病及其沉重的经济负担。 CR 核心将利用当前的临床研究设施和 UC AMC 临床转化中心 Barbara Davis 儿童糖尿病中心 (BDC) 提供的设备 研究中心 (CTRC)、科罗拉多大学医院、丹佛退伍军人管理局医疗中心 （弗吉尼亚州）和科罗拉多州儿童医院。 DRC CR 核心将整合这些领域的糖尿病研究 机构通过沟通和分配可用资源，创建共享样本和 数据生物库和患有糖尿病的母亲、婴儿、儿童、青少年和成人的招募数据库， 糖尿病风险和控制。这种整合将加速进展并提高糖尿病的质量 研究、整合现有优势并战略性地将师资招聘集中在需要的领域 生长。刚果民主共和国的资金还将吸引研究生和初级教师级别的新人才，并增加 发现所需的基础设施的独特组件。 具体来说，我们将改善招募受试者、跟踪数据和银行组织的访问和协作 来自表型良好的糖尿病参与者和对照受试者整个生命周期的样本；建立 从我们特征明确的受试者中收集样本，并提高 DRC 用户的执行能力 利用最先进的技术对外周血、血清和血浆进行测定；改善提供 专门的诊断和分析服务。