Clinical Resource Core

临床资源核心 数据摘要/摘要 糖尿病是一种全球性的健康危机，1型糖尿病（T1 D）和2型糖尿病的发病率都很高。 2型糖尿病（T2 D）的发病率不断上升。虽然自身免疫是T1 D的核心，但该疾病的许多关键方面 T1 D和T2 D共有的过程包括β细胞功能障碍、高血糖症、代谢功能障碍和 胰岛素抵抗T1 D和T2 D的并发症也有许多相似之处，包括心血管疾病 (CVD)和糖尿病肾病（DKD），两者都是发病率和死亡率的主要原因。大学 科罗拉多安舒茨医学中心（UC AMC）是世界领先的临床转化研究， T1 D和T2 D在整个生命周期中，以及妊娠糖尿病（GDM）和囊性纤维化相关糖尿病 （CFRD）。通过糖尿病研究中心（DRC）的资金将利用这些现有的 它的优势和促进形成一个综合全面的糖尿病研究计划。 加州大学丹佛分校DRC的临床资源核心（CR）站在多个机构，计划的接口 和个人，他们都在努力预防或改善破坏性的长期并发症， 糖尿病及其沉重的经济负担。CR核心将利用现有的临床研究设施， 设备可在芭芭拉戴维斯中心儿童糖尿病（BDC），加州大学AMC的临床翻译 研究中心（CTRC），科罗拉多大学医院，丹佛退伍军人管理医疗中心 (VA)和科罗拉多儿童医院DRC CR核心将整合糖尿病研究， 机构通过沟通和分配可用的资源，并创建共享的样本， 数据生物库和糖尿病母亲、婴儿、儿童、青少年和成人的招募数据库， 糖尿病风险与控制这种整合将加速进展并提高糖尿病的质量 研究，合并现有的优势和战略重点在需要的领域教师招聘 增长DRC的资金还将吸引研究生和初级教师级别的新人才， 发现所需的基础架构的独特组件。 具体来说，我们将改善招募受试者、跟踪数据和组织库的访问和合作 从整个生命周期中表型良好的糖尿病参与者和对照受试者的样本;建立 从我们的良好特征的主题收集样品，并促进DRC用户执行的能力 利用现有技术水平的外周血、血清和血浆的测定;改善 专业的诊断和分析服务。

CLINICAL RESOURCE CORE PROGRAM SUMMARY/ABSTRACT Diabetes represents a worldwide health crisis, with the incidence of both type 1 diabetes (T1D) and type 2 diabetes (T2D) steadily increasing. While autoimmunity is central to T1D, many key aspects of the disease process are shared by T1D and T2D, including beta cell dysfunction, hyperglycemia, metabolic dysfunction and insulin resistance. Complications of T1D and T2D also have many similarities, including cardiovascular disease (CVD) and diabetic kidney disease (DKD), both leading causes of morbidity and mortality. The University of Colorado Anschutz Medical Center (UC AMC) is among world leaders in clinical translational investigations into T1D and T2D across the lifespan, as well as in gestational diabetes (GDM) and cystic fibrosis-related diabetes (CFRD). Funding through the Diabetes Research Center (DRC) would capitalize on these existing strengths and catalyze the formation of an integrated comprehensive diabetes research program. The Clinical Resource Core (CR) of the UC Denver DRC stands at the interface of multiple institutions, programs and individuals, all of whom are working to prevent or ameliorate the devastating long term complications of diabetes and its high economic burden. The CR core would leverage the current clinical research facilities and equipment available at the Barbara Davis Center for Childhood Diabetes (BDC), UC AMC’s Clinical Translational Research Center (CTRC), The University of Colorado Hospital, Denver Veteran’s Administration Medical Center (VA) and Children’s Hospital Colorado. The DRC CR core would integrate diabetes research across these institutions through communication and distribution of the resources available, and create shared sample and data biobanks and a recruiting database of mothers, infants, children, adolescents and adults with diabetes, diabetes risk and controls. Such integration would accelerate progress and increase the quality of diabetes research, coalesce existing strengths and strategically focus faculty recruitment in areas of needed growth. DRC funding would also attract new talent at postgraduate and junior faculty levels and add unique components of infrastructure needed for discovery. Specifically, we will improve access and collaborations for recruiting subjects, tracking data and banking tissue samples from well-phenotyped participants with diabetes and control subjects across the lifespan; establish collections of samples from our well-characterized subjects and facilitate the ability of DRC users to perform assays from peripheral blood, serum and plasma utilizing state of the art techniques; improve provision of specialized diagnostic and analytic services.