Developing Pediatric Diabetes Investigators for the Future

培养未来的儿科糖尿病研究人员

• 批准号: 9188204
• 负责人: MARIAN J REWERS
• 金额: $ 39.51万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9188204
• 关键词: Adult; Area; Autoimmune Process; Autoimmunity; Basic Science; Behavioral Research; Biochemical; Biochemistry; Biology; Center for Translational Science Activities; Childhood; Clinical; Clinical Sciences; Colorado; Development; Developmental Biology; Diabetes Mellitus; Doctor of Philosophy; Drug Kinetics; Endocrinologist; Epidemiologic Studies; Epidemiology; Ethics; Functional disorder; Funding; Future; Genetic; Healthcare; Human; Human Genetics; Immune Tolerance; Immunology; Institutes; Insulin-Dependent Diabetes Mellitus; Investigation; Islet Cell; Master of Science; Medical; Medical Genetics; Medical Research; Medicine; Mentors; Molecular Biology; Molecular Genetics; Non-Insulin-Dependent Diabetes Mellitus; Pediatric Hospitals; Physicians; Population; Prevention; Public Health; Public Health Schools; Published Comment; Research; Research Institute; Research Methodology; Research Personnel; Research Training; Scientist; Technology; Training; Translational Research; United States National Institutes of Health; Universities; Work; Writing; career development; design; experience; faculty mentor; health economics; improved; medical schools; multidisciplinary; new technology; next generation; pediatric department; programs; statistics

SUMMARY ABSTRACT This application is a proposal for a career development program for pediatric endocrinologists, designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC), The University of Colorado School of Medicine (UC SOM) and the wider Anschutz Medical Campus (AMC). The proposal’s rationale is: 1) there is a critical nationwide shortage of pediatric endocrinologists trained and experienced in T1D and T2D research 2) diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economics viewpoint 3) current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out basic and translational research in pediatric T1D and T2D to bring advances in diabetes research to the clinical arena. The BDC has an extensive and proven record in research training of young investigators. The BDC and AMC have a well-established network of investigators working in the epidemiology, new diabetes technology, immuno-biology, genetics, and molecular biology of T1D diabetes, as well as the abnormal pathophysiology of T2D. This network of experienced mentors is ideally suited to develop the next generation of pediatric endocrinologists into independent diabetes investigators in high impact T1D and T2D research. Areas of research focus within The BDC include islet cell development, genetics, molecular biology, immunology and the autoimmunity, prediction and prevention of type 1 diabetes, and the epidemiology, prevention and improved treatment, including new technology advancement, of T1D and T2D. These areas of research are urgently needed and have been identified as important to the national public health to improve diabetes treatment in the US. This application is enhanced by the NIH supported Colorado Clinical and Translational Sciences Institute (CCTSI), Pediatric and Adult Clinical Translational Research Centers, as well as a strong Masters of Science in Public Health and in Clinical Science and PhD programs in the Colorado School of Public Health (CSPH) and the CCTSI. This application has the support of the Departments of Pediatrics, Medicine, The CSPH, and Children’s Hospital Colorado. The ability to provide excellent didactic coursework in statistics, epidemiology, research methods, ethics of human research, medical writing, biochemistry, pharmacokinetics, molecular and developmental biology, as well as human medical and molecular genetics through the CCTSI, the BDC and the CSPH combined with a strong mentoring faculty at the BDC, UCSOM and CSPH will allow us to provide the career development for pediatric endocrinologists producing independent investigators, capable of competing for funding in high quality diabetes research. Other programs within AMC that are supportive of this program include the Program in Human Genetics, the Immune Tolerance Network, the Autoimmune Prevention Center and Children’s Hospital Research Institute.

摘要 该申请是儿科内分泌学家职业发展计划的提案，旨在 提供糖尿病研究的多学科培训在芭芭拉戴维斯中心（BDC），大学 科罗拉多医学院（UC SOM）和更广泛的安舒茨医学院（AMC）。该提案的 理由是：1）全国范围内严重缺乏经过培训和经验丰富的儿科内分泌学家， T1 D和T2 D研究2）糖尿病是儿科人群中日益严重的医疗保健问题 从个人和健康经济学的角度来看，这会带来毁灭性的后果; 3）目前， 糖尿病调查需要增加在临床，生物化学， 流行病学和行为研究，以开展儿科T1 D的基础和转化研究， T2 D将糖尿病研究的进展带到临床竞技场。BDC有着广泛而可靠的记录 年轻研究人员的研究培训。BDC和AMC拥有完善的调查人员网络 在流行病学，新的糖尿病技术，免疫生物学，遗传学和分子生物学的工作， T1 D糖尿病，以及T2 D的异常病理生理学。这个经验丰富的导师网络是理想的 适合将下一代儿科内分泌学家培养成独立的糖尿病研究者， 高影响力的T1 D和T2 D研究。BDC的研究重点领域包括胰岛细胞发育， 遗传学、分子生物学、免疫学和自身免疫，预测和预防1型糖尿病， 以及T1 D的流行病学、预防和改进的治疗，包括新技术的进步， 2型糖尿病这些研究领域是迫切需要的，并已被确定为对国家公众很重要 改善美国的糖尿病治疗。该应用程序由NIH支持的科罗拉多 临床和转化科学研究所（CCTSI），儿科和成人临床转化研究 中心，以及在公共卫生和临床科学和博士课程的强大的硕士学位， 科罗拉多公共卫生学院（CSPH）和CCTSI。此应用程序得到了 儿科、内科、CSPH和科罗拉多儿童医院。能够提供 在统计学、流行病学、研究方法、人类研究伦理学、医学方面的优秀教学课程 写作，生物化学，药代动力学，分子和发育生物学，以及人类医学和 分子遗传学通过CCTSI，BDC和CSPH与强大的指导教师相结合， BDC，UCSOM和CSPH将使我们能够为儿科内分泌学家提供职业发展 培养独立的研究人员，能够在高质量的糖尿病研究中竞争资金。其他 AMC内部支持这一计划的计划包括人类遗传学计划、免疫学计划、 耐受网络，自身免疫预防中心和儿童医院研究所。