Developing Pediatric Diabetes Investigators for the Future

摘要摘要 此申请是针对儿科内分泌科医生的职业发展计划提出的建议，旨在 在加州大学芭芭拉·戴维斯中心(BDC)提供糖尿病研究方面的多学科培训 科罗拉多医学院(UC SOM)和更广泛的安舒茨医学院(AMC)。该提案的 理由是：1)全国范围内严重缺乏在以下方面培训和经验丰富的儿科内分泌学家 T1D和T2D研究2)糖尿病在儿科人群中是一个日益严重的健康问题 从个人和健康经济学的角度来看，这带来了毁灭性的后果3)目前 糖尿病调查需要更多的内科科学家接受临床、生化、 流行病学和行为学研究，以开展儿科T1D和T1D的基础和翻译研究 T2D将糖尿病研究的进展带入临床领域。BDC拥有广泛和经过验证的记录 在青年研究人员的研究培训方面。BDC和AMC拥有完善的调查网络 在流行病学、糖尿病新技术、免疫生物学、遗传学和分子生物学方面工作 T1D糖尿病，以及T2D的异常病理生理。这个由经验丰富的导师组成的网络是理想的 适合将下一代儿科内分泌学家培养成独立的糖尿病研究人员 高影响力的T1D和T2D研究。BDC内的研究重点领域包括胰岛细胞发育， 遗传学、分子生物学、免疫学和1型糖尿病的自身免疫、预测和预防， 以及T1D和T1D的流行病学、预防和改进治疗，包括新技术的进步 T2D。这些领域的研究是迫切需要的，并已被确定为对国家公众重要 健康来改善美国的糖尿病治疗。此应用程序由美国国立卫生研究院支持的科罗拉多州增强 临床和翻译科学研究所(CCTSI)，儿科和成人临床翻译研究 中心，以及在公共卫生和临床科学和博士课程的强大硕士学位 科罗拉多州公共卫生学院(CSPH)和CCTSI。此应用程序得到了 科罗拉多州儿科、内科、CSPH和儿童医院。能够提供 统计学、流行病学、研究方法、人类研究伦理学、医学 写作、生物化学、药代动力学、分子和发育生物学，以及人类医学和 分子遗传学通过CCTSI、BDC和CSPH与强大的指导能力相结合 BDC、UCSOM和CSPH将使我们能够为儿科内分泌科医生提供职业发展 产生独立的研究人员，有能力在高质量的糖尿病研究中竞争资金。其他 AMC内部支持这一计划的计划包括人类遗传学计划、免疫计划 耐受性网络、自身免疫预防中心和儿童医院研究所。

SUMMARY ABSTRACT This application is a proposal for a career development program for pediatric endocrinologists, designed to provide multidisciplinary training in diabetes research at The Barbara Davis Center (BDC), The University of Colorado School of Medicine (UC SOM) and the wider Anschutz Medical Campus (AMC). The proposal’s rationale is: 1) there is a critical nationwide shortage of pediatric endocrinologists trained and experienced in T1D and T2D research 2) diabetes is an increasingly significant healthcare problem in the pediatric population with devastating consequences from a personal and health economics viewpoint 3) current rapid advances in diabetes investigation calls for an increased pool of physician scientists trained in clinical, biochemical, epidemiological, and behavioral research to carry out basic and translational research in pediatric T1D and T2D to bring advances in diabetes research to the clinical arena. The BDC has an extensive and proven record in research training of young investigators. The BDC and AMC have a well-established network of investigators working in the epidemiology, new diabetes technology, immuno-biology, genetics, and molecular biology of T1D diabetes, as well as the abnormal pathophysiology of T2D. This network of experienced mentors is ideally suited to develop the next generation of pediatric endocrinologists into independent diabetes investigators in high impact T1D and T2D research. Areas of research focus within The BDC include islet cell development, genetics, molecular biology, immunology and the autoimmunity, prediction and prevention of type 1 diabetes, and the epidemiology, prevention and improved treatment, including new technology advancement, of T1D and T2D. These areas of research are urgently needed and have been identified as important to the national public health to improve diabetes treatment in the US. This application is enhanced by the NIH supported Colorado Clinical and Translational Sciences Institute (CCTSI), Pediatric and Adult Clinical Translational Research Centers, as well as a strong Masters of Science in Public Health and in Clinical Science and PhD programs in the Colorado School of Public Health (CSPH) and the CCTSI. This application has the support of the Departments of Pediatrics, Medicine, The CSPH, and Children’s Hospital Colorado. The ability to provide excellent didactic coursework in statistics, epidemiology, research methods, ethics of human research, medical writing, biochemistry, pharmacokinetics, molecular and developmental biology, as well as human medical and molecular genetics through the CCTSI, the BDC and the CSPH combined with a strong mentoring faculty at the BDC, UCSOM and CSPH will allow us to provide the career development for pediatric endocrinologists producing independent investigators, capable of competing for funding in high quality diabetes research. Other programs within AMC that are supportive of this program include the Program in Human Genetics, the Immune Tolerance Network, the Autoimmune Prevention Center and Children’s Hospital Research Institute.