EFCTS FREE FATTY ACID-INDCD ENDTHLIAL DYSFNCTN&INSULIN RSISTNC ON EXRCZ CPCTY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. People who are overweight or have diabetes have higher levels of certain fats in their blood. The blood vessels and hearts of most of these individuals do not work normally and diabetic individuals also are not as able to exercise as people without diabetes. The purpose of this study is to see whether temporarily increasing these same fats in the blood of healthy people to the same degree will temporarily cause the same changes in the way blood vessels work and in the ability to exercise. This will help us to understand ways of improving blood vessel function and the ability to exercise effectively in people who are overweight or have diabetes