DELINEATION OF PHENOTYPES AND GENETIC MARKERS IN YOUNG OBESE CHILDREN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 最近，青春期前儿童的肥胖率出现了前所未有的上升。 这种上升并没有影响到所有儿童，而只是影响到那些具有某些遗传-环境相互作用的儿童。 使用IRB批准的2006年在CMH诊所看到的超重儿童数据库，我们可以确定数百名极度超重的幼儿进行深入研究，这些研究可能揭示遗传和环境因素。 第一项研究的目的是收集信息，使我们能够识别超重青春期前儿童的表型，并在识别这些表型时探索其遗传基础。 我们收集超重儿童的信息（年龄和性别的BMI大于第97百分位数）;对这些儿童，父母和兄弟姐妹进行身体测量和血液检查;并获得家族史，饮食和活动习惯。 所有受试者的体格测量包括身高、体重、腰围、体脂百分比（通过阻抗）和血压。 指数儿童也评估坦纳阶段和黑棘皮病。 获得的实验室包括：空腹血脂; 2小时口服葡萄糖耐量试验（孕妇和患有糖尿病的父母除外）; ALT; DNA（储存以备将来使用）;以及血液以供将来分析。 索引儿童也有一个全身DEXA扫描。 我们计划招收一百五十（150）个家庭。这将产生多达600个受试者，包括孩子，父母和一个兄弟姐妹。 第一阶段由内部资金和GCRC支持资助，将包括约40个家庭。收集的数据将允许初步分析家族表型因素聚类，以及表型与饮食和活动习惯的关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recently, there has been an unprecedented rise of obesity in prepubertal children. This rise has not impacted all children, but only those with certain genetic-environmental interactions. Using an IRB -approved database of overweight children seen at CMH clinics in 2006, we can identify hundreds of extremely overweight young children for intensive studies that may reveal contributing genetic and environmental factors. The purpose of this first study is to collect information that will allow us to identify phenotypes in overweight pre-pubertal children, and also to explore genetic bases of these phenotypes when they are identified. We collect information on overweight children (greater than 97th percentile BMI for age and gender); take physical measurements and blood tests on these children, parents and siblings; and obtain family histories, and eating and activity habits. Physical measurements on all subjects include height, weight, waist circumference, % body fat (by impedence), and blood pressure. Index children also are assessed for Tanner stage and acanthosis nigricans. Labs obtained include: fasting lipids; 2-hour oral glucose tolerance test (except on pregnant mothers and parents with diabetes); ALT; DNA (stored for future use); and blood for future analyses. The index child also has a full body DEXA scan. We seek to enroll one hundred and fifty (150) families. This will yield up to six hundred subjects when including the child, parents, and one sibling. The first phase, funded by internal funds and GCRC support, will include ~40 families. The data collected will allow preliminary analysis of familial phenotype factor clustering, and also the association of phenotypes with eating and activity habits.