IMPACT OF PREGNANCY ON DISPOSITION OF ANTIRETROVIRAL AGENTS IN BLOOD PLASMA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main purpose of this research study is to measure the amount of HIV drugs and HIV virus found in the blood and genital tract of pregnant women in order to see how body changes during the pregnancy affect the HIV drugs, and how these drugs affect the HIV virus in the blood and genital tract. The reason this is being done is to understand if the amount of HIV drugs found in the body during pregnancy are decreased too much so that drugs are no longer working to control the virus or are increased too much which may become toxic to both the woman and the baby. Additionally, the investigators will measure the amount of HIV drugs in umbilical blood at the time of delivery to see how much drug the baby is exposed to in the pregnant woman's body.