IMPACT OF PREGNANCY ON DISPOSITION OF ANTIRETROVIRAL AGENTS IN BLOOD PLASMA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的主要目的是测量孕妇血液和生殖道中发现的HIV药物和HIV病毒的数量，以了解怀孕期间身体的变化如何影响HIV药物，以及这些药物如何影响血液和生殖道中的HIV病毒。 这样做的原因是为了了解在怀孕期间体内发现的艾滋病毒药物的数量是否减少太多，以至于药物不再控制病毒，或者增加太多，这可能对妇女和婴儿都有毒。 此外，研究人员还将在分娩时测量脐带血中艾滋病毒药物的含量，以了解婴儿在孕妇体内暴露了多少药物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main purpose of this research study is to measure the amount of HIV drugs and HIV virus found in the blood and genital tract of pregnant women in order to see how body changes during the pregnancy affect the HIV drugs, and how these drugs affect the HIV virus in the blood and genital tract. The reason this is being done is to understand if the amount of HIV drugs found in the body during pregnancy are decreased too much so that drugs are no longer working to control the virus or are increased too much which may become toxic to both the woman and the baby. Additionally, the investigators will measure the amount of HIV drugs in umbilical blood at the time of delivery to see how much drug the baby is exposed to in the pregnant woman's body.