Clinical Pharmacology & Analytical Chemistry Core

临床药理学

• 批准号: 8329990
• 负责人: Angela D Kashuba
• 金额: $ 29.23万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8329990
• 关键词: AIDS clinical trial group; AIDS prevention; AIDS/HIV problem; Accreditation; Acquired Immunodeficiency Syndrome; Analytical Chemistry; Animals; Antitubercular Agents; Applications Grants; Area; Biological; Biological Assay; Blood; Cells; Cerebrospinal Fluid; Certification; Charge; Chemistry; Clinical; Clinical Pharmacology; Clinical Protocols; Clinical Research; Clinical Trials; Clinical Trials Design; Commit; Communities; Complex; Consultations; Country; Data; Development; Dose; Drug Exposure; Drug Kinetics; Environment; Epidemic; Experimental Designs; Frequencies; Genital system; Goals; HIV; Human; Human Milk; International; Knowledge; Laboratories; Leadership; Malignant Neoplasms; Measures; Mentors; Mentorship; Methods; Nanotechnology; Patients; Pharmaceutical Preparations; Pharmacodynamics; Pharmacology; Plasma; Population; Prevention Research; Prevention strategy; Regulation; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Saliva; Sampling; Services; Site; Spottings; Strategic Planning; Surveys; System; Techniques; Testing; Tissues; Training; Women' s Health; analytical method; cost; drug development; experience; improved; innovation; member; named group; novel; outreach; pharmacodynamic model; pharmacokinetic model; pre-clinical; pre-clinical research; preclinical study; programs; quality assurance; response; simulation; success; tool; user-friendly; web site; working group

The Clinical Pharmacology and Analyfical Chemistry (CPAC) Core contains clinical pharmacology expertise with a CLIA-certified laboratory to support clinical and preclinical HIV/AIDS research among CFAR nvesfigators at UNC, FHl, and RTI. Since the CPAC Core is the only one of its kind within the CFAR system, it also supports a growing number of invesfigators in other CFARs across the country. The CPAC Core consists of experienced scienfists who provide a high level of expertise in trial design, development and validafion of analyfical methods in complex biological matrices to accurately quantify drug exposure, and interpretation of preclinical and clinical pharmacology data. The CPAC Core also provides leadership in HIV prevention strategies, women's health issues, and intemafional pharmacology, and trains domesfic and intemafional invesfigators in pharmacologic and analyfic methods.

临床药理学和分析化学（CPAC）核心包含临床药理学