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Clinical Pharmacology & Analytical Chemistry Core

临床药理学

基本信息

批准号：
8531837
负责人：
Angela D Kashuba
金额：
$ 87.96万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-08-01 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8531837
关键词：
AIDS clinical trial group AIDS prevention AIDS/HIV problem Accreditation Acquired Immunodeficiency Syndrome Analytical Chemistry Animals Antitubercular Agents Applications Grants Area Biological Biological Assay Blood Cells Cerebrospinal Fluid Certification Charge Chemistry Clinical Clinical Pharmacology Clinical Protocols Clinical Research Clinical Trials Clinical Trials Design Commit Communities Complex Consultations Country Data Development Dose Drug Combinations Drug Exposure Drug Kinetics Environment Epidemic Experimental Designs Frequencies Genital system Goals HIV Human Human Milk International Investigation Knowledge Laboratories Leadership Malignant Neoplasms Measures Mentors Mentorship Methods Nanotechnology Patients Pharmaceutical Preparations Pharmacodynamics Pharmacology Plasma Population Prevention Prevention Research Prevention strategy Regulation Research Research Design Research Infrastructure Research Personnel Resources Saliva Sampling Scientist Services Site Spottings Strategic Planning Surveys System Techniques Testing Tissues Training Validation Women&apos s Health analytical method cost drug development effective therapy experience improved innovation member named group novel outreach pharmacodynamic model pharmacokinetic model pre-clinical pre-clinical research preclinical study programs quality assurance response simulation success tool user-friendly web site working group

项目摘要

The Clinical Pharmacology and Analyfical Chemistry (CPAC) Core contains clinical pharmacology expertise with a CLIA-certified laboratory to support clinical and preclinical HIV/AIDS research among CFAR invesfigators at UNC, FHl, and RTI. Since the CPAC Core is the only one of its kind within the CFAR system, it also supports a growing number of invesfigators in other CFARs across the country. The CPAC Core consists of experienced scientists who provide a high level of expertise in trial design, development and validation of analytical methods in complex biological matrices to accurately quantify drug exposure, and interpretation of preclinical and clinical pharmacology data. The CPAC Core also provides leadership in HIV prevention strategies, women's health issues, and international pharmacology, and trains domestic and international investigators in pharmacologic and analytic methods.

临床药理学和分析化学（CPAC）核心包含临床药理学专业知识，并拥有CLIA认证的实验室，以支持CFAR研究人员在CNAS，FHl和RTI进行临床和临床前HIV/AIDS研究。由于CPAC核心是CFAR系统中唯一的同类产品，它还支持全国其他CFAR中越来越多的投资者。CPAC核心由经验丰富的科学家组成，他们在试验设计、开发和验证复杂生物基质中的分析方法以准确量化药物暴露以及解释临床前和临床药理学数据方面提供高水平的专业知识。CPAC核心还在艾滋病毒预防战略，妇女健康问题和国际药理学方面提供领导，并在药理学和分析方法方面培训国内和国际研究人员。