Pharmacology Core

药理学核心

• 批准号: 8326902
• 负责人: Angela D Kashuba
• 金额: $ 22.61万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-08 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8326902
• 关键词: Algorithms; Analytical Chemistry; Animal Model; Animals; Anti-Retroviral Agents; Biological; Biological Assay; Biological Models; Cell Culture Techniques; Cells; Clinical; Clinical Pharmacology; Clinical Trials; Clinical Trials Design; Data; Development; Dose; Drug Exposure; Drug Kinetics; Frequencies; HIV; HIV Infections; HIV-1; Human; Industry; Infection; Lead; Leadership; Logistics; Marketing; Modeling; Monkeys; Mus; North Carolina; Outcome; Pharmaceutical Preparations; Pharmacology; Plasma; Plasma Cells; Production; Research Contracts; Research Design; Research Personnel; Resources; Role; Sampling; Screening procedure; Techniques; Testing; Therapeutic; Therapeutic Studies; Tissues; Toxic effect; Toxicology; Universities; Validation; Viral; base; collaboratory; design; drug development; experience; indexing; mouse model; nonhuman primate; pharmacodynamic model; pre-clinical; preclinical study; scale up; simulation; small molecule; small molecule libraries; success

The role of Preclinical and Clinical Pharmacology is to maximize the likelihood of success of an identified candidate, or to quickly remove a likely unsuccessful candidate from progressing into further testing. The primary objective of the Pharmacology Core (Core B) is to provide the investigators of the Martin Deianey Collaboratory to Eradicate HlV-1 Infection with the pharmacologic expertise to study therapeutic strategies that reduce the latent viral pool and animal model systems, and to evaluate the pharmacologic basis of viral persistence in humans. The Pharmacology Core will coordinate access to chemical libraries, assist with lead candidate production scale-up, coordinate animal toxicology studies, analyze biological matrices for drug concentrations (both antiretroviral and induction/eradication compounds), provide pharmacokinetic/ pharmacodynamic (PK/PD) modeling for optimal dose and dose frequency selection, and perform trial simulation to optimize design and sampling strategies. This Core will participate in all aspects of drug development for identifying and progressing lead induction/eradication candidates. The Core leadership team (Drs. Kashuba and Tan) has over 20 years combined experience in preclinical and clinical pharmacology, analytical chemistry, and Core management, and are well-suited to support the projects in the Collaboratory. This results in a Core which combines academic and industry resources to synergize strengths.

临床前和临床药理学的作用是最大限度地提高已识别药物的成功可能性。 候选人，或快速移除可能不成功的候选人，使其无法进入进一步的测试。的 药理学核心（核心B）的主要目的是为Martin Deianey的研究者提供 利用药理学专业知识研究治疗策略的根除HlV-1感染合作实验室 减少潜伏病毒库和动物模型系统，并评估病毒的药理学基础， 人类的持久性。药理学核心将协调对化学图书馆的访问， 候选产品生产规模扩大，协调动物毒理学研究，分析药物的生物基质 浓度（抗逆转录病毒和诱导/根除化合物），提供药代动力学/ 用于最佳剂量和给药频率选择的药效学（PK/PD）建模，并进行试验 模拟以优化设计和采样策略。该核心将参与药物的各个方面 开发用于确定和推进铅诱导/根除候选药物的方法。核心领导 Kashuba博士和Tan博士的团队在临床前和临床方面拥有超过20年的综合经验 药理学、分析化学和核心管理，非常适合支持以下项目： 合作实验室。这就产生了一个核心，它结合了学术和行业资源， 长处.