Modulating beta-amyloid aggregation and toxicity with natural metal-binding proteins

用天然金属结合蛋白调节 β-淀粉样蛋白聚集和毒性

• 批准号: nhmrc : 605528
• 负责人: A/Pr Paul Adlard
• 金额: $ 26.62万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulating-beta-amyloid-binding-proteins/101020
• 关键词: Modulating; beta; amyloid; aggregation; toxicity

Alzheimer's disease (AD) is a devastating disorder that afflicts millions of people worldwide. It is well established that the small peptide beta-amyloid, has a direct and important role in the development of AD. This project will investigate the ability of a small naturally occurring metal-binding protein to block the toxic actions of beta-amyloid.

阿尔茨海默病（AD）是一种毁灭性的疾病，困扰着全世界数百万人。众所周知，小肽β-淀粉样蛋白在AD的发展中具有直接和重要的作用。该项目将研究一种天然存在的小金属结合蛋白阻断β-淀粉样蛋白毒性作用的能力。