The role of metals in healthy brain aging: identification of novel compounds to prevent age-related cognitive decline

金属在健康大脑老化中的作用：鉴定新化合物以预防与年龄相关的认知能力下降

• 批准号: nhmrc : 1027379
• 负责人: A/Pr Paul Adlard
• 金额: $ 52.66万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-metals-healthy-cognitive-decline/110563
• 关键词: role; metals; healthy; brain; aging

This grant will explore the basic mechanisms that underlie normal learning and memory. Specifically, we are focussing on how the modulation of metal levels may occur with age, and how this may cause or at least contribute to age-related cognitive impairment. We are also examining a novel therapeutic compound for the treatment of cognitive dysfunction. This work will have implications for both normal and pathological ageing.

这项资助将探索正常学习和记忆的基本机制。具体来说，我们关注的是金属水平的调节如何随着年龄的增长而发生，以及这如何导致或至少导致与年龄相关的认知障碍。我们还在研究一种用于治疗认知功能障碍的新型治疗化合物。这项工作将对正常和病理衰老产生影响。