The effect of metals on neurofibrillary tangle formation

金属对神经原纤维缠结形成的影响

• 批准号: nhmrc : 509276
• 负责人: A/Pr Paul Adlard
• 金额: $ 22.23万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-metals-neurofibrillary-tangle-formation/95704
• 关键词: effect; metals; neurofibrillary; tangle; formation

The majority of studies into Alzheimer's disease (AD) have focussed on two brain lesions- the plaque and neurofibrillary tangle (NFT), which are believed to have a causative role in AD. Our lab has made several seminal discoveries about the role that metals play in the development of plaques. We are now extending this work to evaluate the role of metals in NFT formation. These studies will provide insight into the formation and possible treatments for this primary brain lesion in AD.

大多数关于阿尔茨海默病(AD)的研究都集中在两个大脑病变上--斑块和神经原纤维缠结(NFT)，它们被认为在AD中起到了致病作用。我们的实验室已经在金属在斑块形成中所起的作用方面取得了几项开创性的发现。我们现在正在扩展这项工作，以评估金属在NFT形成中的作用。这些研究将为AD的这种原发脑损害的形成和可能的治疗提供洞察力。