Metal-mediated mechanisms and therapeutic approaches for treating brain injury across age

治疗跨年龄脑损伤的金属介导机制和治疗方法

• 批准号: nhmrc : 1141597
• 负责人: A/Pr Paul Adlard
• 金额: $ 83.15万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/metal-mediated-mechanisms-injury-age/1319521
• 关键词: Metal; mediated; mechanisms; therapeutic; approaches

This grant will examine the role of zinc and iron in the neuronal changes that occur following brain injury, with a specific focus on the role of these metals in functional outcomes. We will also examine how the role of these metals changes across the normal lifespan, and also whether these metal changes are consistent across different types of brain injury. Finally, we will examine the therapeutic potential of zinc- and iron-targeted compounds.

这项资助将研究锌和铁在脑损伤后发生的神经元变化中的作用，特别关注这些金属在功能结果中的作用。我们还将研究这些金属在正常寿命中的作用如何变化，以及这些金属的变化是否在不同类型的脑损伤中是一致的。最后，我们将研究锌和铁靶向化合物的治疗潜力。