The role of beta-Amyloid Precursor Protein and Tau in the regulation of neuronal iron

我们最近发现了淀粉样蛋白前体蛋白（APP）与tau蛋白在调节神经元铁平衡中的新关系。该项目将确定tau如何帮助APP运输到细胞表面，在那里它帮助细胞铁释放。一些神经退行性疾病的共性是proteinsÍ功能和铁相关兴奋性毒性的破坏。了解APP和tau蛋白在铁中的作用将有助于了解治疗机制和更好的未来药物设计。

We have recently discovered a novel relationship between amyloid precursor protein (APP) and tau in regulating neuronal iron balance. This project will establish how tau aids APP transport to the cell surface where it assists cellular iron release. A commonality in some neurodegenerative diseases are disruptions in either proteinsÍ function and iron-related excitotoxicity. Understanding the iron role of APP and tau will lead to a therapeutic mechanism of action and better future drug design.