The role of beta-Amyloid Precursor Protein and Tau in the regulation of neuronal iron

β-淀粉样前体蛋白和 Tau 在神经元铁调节中的作用

• 批准号: nhmrc : 1025774
• 负责人: A/Pr Paul Adlard
• 金额: $ 43.36万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-beta-amyloid-neuronal-iron/110452
• 关键词: role; beta; Amyloid; Precursor; Protein

We have recently discovered a novel relationship between amyloid precursor protein (APP) and tau in regulating neuronal iron balance. This project will establish how tau aids APP transport to the cell surface where it assists cellular iron release. A commonality in some neurodegenerative diseases are disruptions in either proteinsÍ function and iron-related excitotoxicity. Understanding the iron role of APP and tau will lead to a therapeutic mechanism of action and better future drug design.

我们最近发现淀粉样前体蛋白（APP）和tau蛋白在调节神经元铁平衡中的新关系。该项目将确定tau如何帮助APP转运到细胞表面，在那里它帮助细胞释放铁。一些神经退行性疾病的共同点是蛋白质代谢功能和铁相关兴奋性毒性的破坏。了解APP和tau的铁作用将导致治疗作用机制和更好的未来药物设计。