课题基金 / 基金详情

The role of beta-Amyloid Precursor Protein and Tau in the regulation of neuronal iron

The role of beta-Amyloid Precursor Protein and Tau in the regulation of neuronal iron
β-淀粉样前体蛋白和 Tau 在神经元铁调节中的作用
批准号:
nhmrc : 1025774
负责人:
A/Pr Paul Adlard
金额:
$43.36万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2012
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2012-01-01 至 2014-12-31

项目摘要

项目成果

A/Pr Paul Adlard的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
We have recently discovered a novel relationship between amyloid precursor protein (APP) and tau in regulating neuronal iron balance. This project will establish how tau aids APP transport to the cell surface where it assists cellular iron release. A commonality in some neurodegenerative diseases are disruptions in either proteinsÍ function and iron-related excitotoxicity. Understanding the iron role of APP and tau will lead to a therapeutic mechanism of action and better future drug design.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Metal-mediated mechanisms and therapeutic approaches for treating brain injury across age
  • 批准号:
    nhmrc : GNT1141597
  • 项目类别:
    Project Grants
  • 资助金额:
    $122.98万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Paul Adlard
  • 依托单位:
Metal-mediated mechanisms and therapeutic approaches for treating brain injury across age
  • 批准号:
    nhmrc : 1141597
  • 项目类别:
    Project Grants
  • 资助金额:
    $83.15万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Paul Adlard
  • 依托单位:
The role of metals in healthy brain aging: identification of novel compounds to prevent age-related cognitive decline
  • 批准号:
    nhmrc : 1027379
  • 项目类别:
    Project Grants
  • 资助金额:
    $52.66万
  • 财政年份:
    2012
  • 负责人:
    A/Pr Paul Adlard
  • 依托单位:
Modulating beta-amyloid aggregation and toxicity with natural metal-binding proteins
国内基金
海外基金
人附睾蛋白4靶向调控TGF beta-smad轴加剧克罗恩病相关肠纤维化进程的作用机制研究
AP2B通过WNT/BETA-CATENIN调控颅骨元件成骨活性差异的 分子机制研究
  • 批准号:
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    孙贤杰
  • 依托单位:
TGF-beta通路通过降低自噬-基因组稳定性介导胶质母细胞瘤间质亚型替莫唑胺耐药的机制研究
  • 批准号:
    82303919
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30万元
  • 批准年份:
    2023
  • 负责人:
    陈鹭跃
  • 依托单位: