COBRE: UMMC: NEUROBEHAV EFFECTS OF EARLY EXPOSURE TO PSYCHOTHERAPEUTIC AGENTS
COBRE:UMMC:早期接触精神治疗药物的神经行为影响
基本信息
- 批准号:7610488
- 负责人:
- 金额:$ 5.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-07-01 至 2008-06-30
- 项目状态:已结题
- 来源:
- 关键词:Antidepressive AgentsBehaviorBehavioralBrainComputer Retrieval of Information on Scientific Projects DatabaseDevelopmentDiscipline of NursingExposure toFetusFundingGrantHumanImpairmentInfantInstitutionMothersMotorNeurobiologyPainPatient currently pregnantPharmaceutical PreparationsPharmacotherapyProteinsResearchResearch PersonnelResourcesRodent ModelSelective Serotonin Reuptake InhibitorSex BehaviorSourceTryptophan 5-monooxygenaseUnited States National Institutes of Healthmaleresponseserotonin transporter
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This research is focused on the effects of early exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants on brain development and behavior. SSRIs are the pharmacotherapy of choice for pregnant and nursing mothers and recent studies have demonstrated that the fetus and nursing infant are exposed to drug concentrations similar to those of the mother. Little is known about the long-term neurobiological effects of early SSRI exposure however, recent studies indicate that such exposure may have lasting increases in irritability and impairment of fine motor behavior and pain sensitivity in humans. In rodent models of early antidepressant exposure, lasting impairment of male sexual behavior and aggressive response has been noted. We have recently demonstrated that the behavioral effects of early antidepressant exposure are also produced by highly selective SSRIs. Moreover, such exposure results in permanent reductions in the expression of tryptophan hydroxylase and the serotonin transporter which are critical proteins regulating serotonergic circuits
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
本研究的重点是早期暴露于选择性5-羟色胺再摄取抑制剂(SSRI)抗抑郁药对大脑发育和行为的影响。SSRIs是孕妇和哺乳期母亲的首选药物治疗,最近的研究表明,胎儿和哺乳期婴儿暴露于与母亲相似的药物浓度。关于早期SSRI暴露的长期神经生物学效应知之甚少,然而,最近的研究表明,这种暴露可能会持续增加人类的易怒和精细运动行为和疼痛敏感性的损害。在早期抗抑郁药暴露的啮齿动物模型中,已注意到雄性性行为和攻击性反应的持久损害。我们最近证明,早期抗抑郁药暴露的行为效应也是由高选择性SSRIs产生的。此外,这种暴露导致色氨酸羟化酶和5-羟色胺转运蛋白表达的永久性减少,这两种蛋白是调节多巴胺能回路的关键蛋白质
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
IAN A. PAUL其他文献
IAN A. PAUL的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('IAN A. PAUL', 18)}}的其他基金
IBUPROFEN ALONE & IN COMBINATION WITH ACETAMINOPHEN FOR FEVER
单独布洛芬
- 批准号:
7951254 - 财政年份:2009
- 资助金额:
$ 5.01万 - 项目类别:
COBRE: UMMC: RR CORE A: FACILITY FOR BEHAVIORAL STUDIES
COBRE:UMMC:RR 核心 A:行为研究设施
- 批准号:
7610484 - 财政年份:2007
- 资助金额:
$ 5.01万 - 项目类别:
IBUPROFEN ALONE & IN COMBINATION WITH ACETAMINOPHEN FOR FEVER
单独布洛芬
- 批准号:
7625782 - 财政年份:2007
- 资助金额:
$ 5.01万 - 项目类别:
COBRE: UMMC: RR CORE A: FACILITY FOR BEHAVIORAL STUDIES
COBRE:UMMC:RR 核心 A:行为研究设施
- 批准号:
7381909 - 财政年份:2006
- 资助金额:
$ 5.01万 - 项目类别:
COBRE: UMMC: NEUROBEHAV EFFECTS OF EARLY EXPOSURE TO PSYCHOTHERAPEUTIC AGENTS
COBRE:UMMC:早期接触精神治疗药物的神经行为影响
- 批准号:
7381913 - 财政年份:2006
- 资助金额:
$ 5.01万 - 项目类别:
相似国自然基金
greenwashing behavior in China:Basedon an integrated view of reconfiguration of environmental authority and decoupling logic
- 批准号:
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国学者研究基金项目
相似海外基金
Systematization of Cognitive Behavioral Therapy based on the influence of rule-governed behavior in frequent stealing behavior
基于规则行为对频繁偷盗行为的影响的认知行为治疗的系统化
- 批准号:
23K18975 - 财政年份:2023
- 资助金额:
$ 5.01万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Organizational Behavior Management in Various Welfare Facilities Starting with Behavioral Records
各类福利机构的组织行为管理从行为记录入手
- 批准号:
23K17566 - 财政年份:2023
- 资助金额:
$ 5.01万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
An Empirical Study on a Behavioral Model for Invoking the Potential Demand of Micro-Tourism through the Provision of Behavior Change Triggers
通过提供行为改变触发因素激发微旅游潜在需求的行为模型实证研究
- 批准号:
23K11632 - 财政年份:2023
- 资助金额:
$ 5.01万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of behavior modification approach using cognitive behavioral therapy for patients with higher brain dysfunction
使用认知行为疗法开发针对重度脑功能障碍患者的行为矫正方法
- 批准号:
23K02986 - 财政年份:2023
- 资助金额:
$ 5.01万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Combined Dialectical Behavior Therapy and Digital Cognitive Behavioral Therapy for Insomnia for Adolescents at High Risk for Suicide: A Pilot RCT
辩证行为疗法和数字认知行为疗法相结合治疗自杀高危青少年的失眠:一项试点随机对照试验
- 批准号:
10643478 - 财政年份:2023
- 资助金额:
$ 5.01万 - 项目类别:
The Effects of Scholarship on Student's Learning Behavior Focusing on PreferenceDevelopments and Expansions of Behavioral Economics Approach
奖学金对学生学习行为的影响关注偏好行为经济学方法的发展和扩展
- 批准号:
22K13722 - 财政年份:2022
- 资助金额:
$ 5.01万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Multisensory integration at the cell, circuit, and behavioral levels: How audiovisual signals drive dynamic courtship behavior in Drosophila melanogaster
细胞、回路和行为层面的多感觉整合:视听信号如何驱动果蝇的动态求偶行为
- 批准号:
10389197 - 财政年份:2022
- 资助金额:
$ 5.01万 - 项目类别:
Multisensory integration at the cell, circuit, and behavioral levels: How audiovisual signals drive dynamic courtship behavior in Drosophila melanogaster
细胞、回路和行为层面的多感觉整合:视听信号如何驱动果蝇的动态求偶行为
- 批准号:
10828249 - 财政年份:2022
- 资助金额:
$ 5.01万 - 项目类别:
Quantifying Behavioral Factors Related to Sedentary Behavior of Disabled Elderly
量化与残疾老年人久坐行为相关的行为因素
- 批准号:
22K21213 - 财政年份:2022
- 资助金额:
$ 5.01万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Construction of tsunami evacuation behavior database containing geographic characteristics and behavioral contexts and utilization of it for promoting residents' behavior to prepare for evacuation
构建包含地理特征和行为背景的海啸疏散行为数据库,并利用它来促进居民做好疏散准备的行为
- 批准号:
22K04641 - 财政年份:2022
- 资助金额:
$ 5.01万 - 项目类别:
Grant-in-Aid for Scientific Research (C)