MENTORING IN CARDIOVASCULAR BIOLOGY

描述(由申请人提供)： Cobre申请的目标是在心血管生物学的多学科和跨部门努力中指导一批杰出的新研究人员。这一努力是发展我们的心血管研究卓越中心的广泛机构倡议的支柱之一。第一批接受指导的科学家刚刚被招募到路易斯安那州立大学健康科学中心，他们的项目围绕着血管生物学和细胞信号转导展开：1)PARP-1与血管系统中的氧化应激；2)基因转移、氧化应激与糖尿病血管疾病；3)生长因子和整合素信号在血管平滑肌细胞中的整合；以及4)心肌细胞和血管平滑肌细胞中信号蛋白从内质网到高尔基体的转运。这些项目汇聚了一批具有独特视角和才华的科学家。这些导师都是杰出的科学家，拥有既定的和互补的研究项目，有为各种研究项目提供成功资金的历史，以及长期的指导记录。该倡议得到了核心设施的支持：细胞和分子、心脏和血管功能以及组织学。第二批受指导的科学家将在第三年和第四年进入该项目，作为生理和药理学系以及心血管研究中心招聘增长计划的一部分。预计至少有9名接受指导的调查人员将通过该计划入学。LSU-HSC在这一倡议中进行了大量投资，招募了新的药理学和生理学负责人，他们担任这一提案的主任和联席主任。推动这一计划的综合合作伙伴关系将是其成功的关键，并为协同增长、高质量指导和原始发现提供独特的机会。这一指导计划将增加心血管生物学研究的资助教员基础，并为取得重大影响我们对心血管疾病的理解提供一个平台，并为这些疾病的治疗管理提供新的途径。

DESCRIPTION (provided by applicant): The objective of this COBRE application is to mentor a group of outstanding new investigators within the multidisciplinary and interdepartmental effort in cardiovascular biology. This effort is one pillar of a broad institutional initiative to develop our Center of Excellence in Cardiovascular Research. The first group of mentored scientists were just recruited to LSU Health Sciences Center and their projects are centered around vascular biology and cell signaling: 1) PARP-1 and oxidant stress in the vasculature; 2) Gene transfer, oxidant stress and diabetic vascular disease; 3) Integration of growth factor and integrin signaling in vascular smooth muscle cells; and 4) ER to Golgi trafficking of signaling proteins in cardiac myocytes and vascular smooth muscle cells. These programs bring together a number of scientists with unique perspectives and talents. The mentors are outstanding scientists with established and complementary research programs, a history of funding success for their various research programs, and long-standing records of mentoring. The initiative is supported by core facilities: Cell and Molecular, Cardiac and Vascular Function, and Histology. The second group of mentored scientists will enter the program in years 3 and 4 as part of a growth plan for recruitment in the Departments of Physiology and Pharmacology along with the Cardiovascular Research Center. It is anticipated that a minimum of nine mentored investigators will matriculate through the program. LSU-HSC has made a substantial investment in this initiative with the recruitment of new Heads of Pharmacology and Physiology, which serve as the Director and Co-Director of this proposal. The integrated partnerships that drive this program will be the key to its success and offer unique opportunities for synergistic growth, high quality mentoring and the original discovery. This mentoring program will increase the funded faculty base for research in cardiovascular biology and provide a platform for advances that will significantly impact our understanding of cardiovascular diseases and provide new avenues for therapeutic management of these diseases.