Mentoring in Cardiovascular Biology

描述（由申请人提供）：我们的生物医学研究卓越中心（COBRE）项目的第三阶段的目标是继续提供强大的基础设施，核心实验室支持，以及必要的大学科学环境，以指导杰出的研究人员，并促进路易斯安那州立大学健康科学中心-新奥尔良（LSUHSC-NO）心血管生物学多学科和跨部门的合作。我们一期和二期COBRE项目的首要任务之一是通过将初级研究员从COBRE支持过渡到ro1资助状态来增加NIH-RO1在心血管生物学方面的资助数量，并使这些人走上成功的研究职业道路。这一努力是一个重要的一步，广泛的机构倡议，以发展卓越的心血管中心在LSUHSC。在过去10年的资助下，我们建立了三个科学核心设施，这些设施在推进COBRE和LSUHSC研究人员的科学项目方面发挥了重要作用。通过我们的项目，我们已经培养了16名优秀的小调查员。其中，14人因其COBRE项目获得了NIH和/或美国心脏协会的校外资助奖励。因此，需要第三阶段的支持来维持我们在过去10年里开发的强大的基础设施和指导环境，因为我们完成了从COBRE到机构支持的项目过渡。以下是第三阶段计划的具体目标：1)提供支持，以维持和加强COBRE核心设施的基础设施和使用，这对我们中心在LSUHSC的心血管研究任务的功能至关重要；2)通过支持COBRE试点项目和本中心的指导任务，进一步增加LSUHSC心血管疾病领域研究项目的研究人员的临界质量；心血管生物学的多学科和跨部门研究项目，促进基础科学家和临床科学家之间的合作关系。完成从COBRE支持的项目到由州和联邦资助的全国认可的跨学科卓越中心的过渡。

DESCRIPTION (provided by applicant): The objective of our Phase IIl Center of Biomedical Research Excellence (COBRE) program is to continue to provide the strong infrastructure, core laboratory support, and collegial scientific environment necessary to mentor outstanding investigators and foster collaborations within the multidisciplinary and interdepartmental effort i cardiovascular biology at the Louisiana State University Health Sciences Center-New Orleans (LSUHSC-NO). One of the top priorities of our Phase I and Phase II COBRE program has been to increase the number of NIH-RO1 grants in cardiovascular biology by transitioning Junior Investigators from COBRE support to RO1-funded status and to launch these individuals on a successful research career path. This effort has been one major step to a broad institutional initiative to develop a Cardiovascular Center of Excellence at LSUHSC. Over the last 10 years of funding, we built three scientific core facilities that have been instrumental in advancing the scientific programs of COBRE and fellow researchers at LSUHSC. We have matriculated 16 outstanding Jr. Investigators through our program. Of these, 14 received extramural grant awards from NIH and/or the American Heart Association stemming from their COBRE projects. Thus, Phase III support is required to sustain the strong infrastructure and mentoring environment we have developed over the past 10 years as we finalize the transition of our program from COBRE to Institutional support. The following are the Specific Aims of the Phase III program: 1) To provide support to sustain and enhance the infrastructure and use of COBRE Core Facilities, which have been pivotal to the function of our Center's cardiovascular research mission at LSUHSC, 2) To further increase the critical mass of investigators at LSUHSC with research programs in the area of cardiovascular disease through the support of COBRE Pilot Projects and the mentoring mission of our Center, 3) To expand the thematic, multidisciplinary and interdepartmental research program in cardiovascular biology which fosters collaborative relationships between basic and clinician-scientists, 4). To finalize the transition from a COBRE supported program to a nationally recognized, interdisciplinary Center of Excellence with state and federal funding.