MENTORING IN CARDIOVASCULAR BIOLOGY

心血管生物学辅导

• 批准号: 8311093
• 负责人: DANIEL R KAPUSTA
• 金额: $ 201.86万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8311093
• 关键词: Achievement; Advisory Committees; Applications Grants; Area; Award; Basic Science; Biology; Biomedical Research; Businesses; Cardiovascular Diseases; Cardiovascular system; Centers of Research Excellence; Clinical; Collaborations; Commit; Core Facility; Department of Defense; Development; Disease Progression; Ensure; Environment; Faculty; Financial Support; Fostering; Foundations; Functional disorder; Funding; Goals; Grant; Growth; Health Sciences; Hurricane; Leadership; Louisiana; Medicine; Mentors; Molecular; Pilot Projects; Postdoctoral Fellow; Program Development; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Schools; Scientist; Services; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Veterinary Medicine; base; career; expectation; improved; infrastructure development; interest; multidisciplinary; outreach; pre-doctoral; programs; success

The overall objectives for this COBRE renewal application is to build upon the successes accomplished during the previous funding period by continuing to expand and improve Cardiovascular Research at the Louisiana State University Health Sciences center-New Orleans (LSUHSC-NO) through support of thematic, multi-disciplinary and multi-institutional programs and enhanced infrastructure capabilities. The initial funding through this grant established a cadre of talented cardiovascular researchers at LSUHSC-NO that have made significant contributions to the basic understanding of molecular mechanisms that underlie cardiovascular pathophysiology. Through the strong leadership, committed mentoring, an interactive relationship with the External Advisory Committee and state-of-the-art Core facilities, we have achieved a record career advancement of 8 of 9 targeted faculty, 5 NIH RO1 grants, 2 NIH R21 grants, 4 AHA Basic Grant- In-Aid and 2 Scientist Development Grants, and 2 faculty sponsored Pre- and Postdoctoral Fellow Grant awards (AHA and Department of Defense). The renewal builds upon strength of the original program to achieve a more ambitious goal of an established Cardiovascular Center of Excellence though program grant applications focusing on translational cardiovascular research. To this end, we are requesting support in this renewal application for the research programs of 7-8 junior and promising developing investigators who will receive tailored one-on-one and team mentoring, the support for 3 scientific core facilities and 1 administrative core that has strong business administration and management, faculty development, and program development components. The Specific Aims of this COBRE renewal are: Aim 1. To expand the critical mass of NIH funded investigators at the LSUHSC-NO with research programs in the area of cardiovascular disease progression. Aim 2. To enhance the infrastructure and support of existing and new core facilities that will continue to provide state-of-the-art research resources to promising junior and established investigators. Aim 3. To provide an exit strategy that will complete the intellectual foundation and technological platform to transition from a COBRE supported project to a nationally recognized, interdisciplinary translational Cardiovascular Center of Excellence. This proposal will build effective scientific collaborations between basic and clinician scientists for PPG, SCCOR and CTSA funding that will sustain the Cardiovascular Center beyond completion of COBRE funding.

本次COBRE更新申请的总体目标是在上一个资助期取得成功的基础上，通过支持主题、多学科和多机构项目以及增强的基础设施能力，继续扩大和改善路易斯安那州立大学健康科学中心-新奥尔良（LSUHSC-NO）的心血管研究。通过这笔赠款的初始资金在LSUHSC-NO建立了一支有才华的心血管研究人员队伍，这些研究人员对心血管病理生理学基础的分子机制的基本理解做出了重大贡献。通过强有力的领导，坚定的指导，与外部咨询委员会和最先进的核心设施的互动关系，我们已经实现了9个目标教师中的8个，5个NIH RO 1赠款，2个NIH R21赠款，4个AHA基本赠款-援助和2个科学家发展赠款的创纪录的职业发展，和2个教师赞助的前和博士后研究员补助金奖（AHA和国防部）。 更新建立在原有计划的基础上，通过专注于转化心血管研究的计划拨款申请，实现了建立心血管卓越中心的更雄心勃勃的目标。为此，我们要求在此更新申请中支持7-8名初级和有前途的发展研究人员的研究计划，他们将接受量身定制的一对一和团队指导，支持3个科学核心设施和1个具有强大的企业管理和管理，教师发展和计划开发组件的行政核心。本次COBRE更新的具体目标是：目标1。扩大NIH资助的研究人员在LSUHSC-NO的临界质量，在心血管疾病进展领域开展研究项目。目标2.加强现有和新的核心设施的基础设施和支持，继续为有前途的初级和成熟的研究人员提供最先进的研究资源。目标3.提供退出策略，完成知识基础和技术平台，从COBRE支持的项目过渡到国家认可的跨学科转化心血管卓越中心。该提案将在基础科学家和临床科学家之间建立有效的科学合作，以获得PPG、SCCOR和CTSA资金，从而在COBRE资金完成后维持心血管中心的运转。