MENTORING IN CARDIOVASCULAR BIOLOGY

描述（由申请人提供）：本次COBRE续期申请的总体目标是通过支持主题、多学科、多机构的项目和增强的基础设施能力，继续扩大和改善路易斯安那州立大学健康科学中心-新奥尔良（LSUHSC-NO）的心血管研究，以此在上一个资助期内取得的成功为基础。通过这笔拨款的初始资金在LSUHSC-NO建立了一支有才华的心血管研究人员骨干队伍，他们为这项研究做出了重大贡献

DESCRIPTION (provided by applicant): The overall objectives for this COBRE renewal application is to build upon the successes accomplished during the previous funding period by continuing to expand and improve Cardiovascular Research at the Louisiana State University Health Sciences center-New Orleans(LSUHSC-NO) through support of thematic, multi-disciplinary and multi-institutional programs and enhanced infrastructure capabilities. The initial funding through this grant established a cadre of talented cardiovascular researchers at LSUHSC-NO that have made significant contributions to the basic understanding of molecular mechanisms that underlie cardiovascular pathophysiology. Through the strong leadership, committed mentoring, an interactive relationship with the External Advisory Committee and state-of-the-art Core facilities, we have achieved a record career advancement of 8 of 9 targeted faculty members, 5 NIH RO1 grants, 2 NIH R21 grants, 4 AHA Basic Grant- In-Aid and 2 Scientist Development Grants, and 2 faculty members sponsored Pre- and Postdoctoral Fellow Grant awards (AHA and Department of Defense). The renewal builds upon strength of the original program to achieve a more ambitious goal of an established Cardiovascular Center of Excellence though program grant applications focusing on translational cardiovascular research. To this end, we are requesting support in this renewal application for the research programs of 7-8 junior and promising developing investigators who will receive tailored one-on-one and team mentoring, the support for 3 scientific Core facilities and 1 administrative core that has strong business administration and management, faculty members development, and program development components. The Specific Aims of this COBRE renewal are: Aim 1. To expand the critical mass of NIH funded investigators at the LSUHSC-NO with research programs in the area of cardiovascular disease progression. Aim 2. To enhance the infrastructure and support of existing and new core facilities that will continue to provide state-of-the-art research resources to promising junior and established investigators. Aim 3. To provide an exit strategy that will complete the intellectual foundation and technological platform to transition from a COBRE supported project to a nationally recognized, interdisciplinary translational Cardiovascular Center of Excellence. This proposal will build effective scientific collaborations between basic and clinician scientists for PPG, SCCOR and CTSA funding that will sustain the Cardiovascular Center beyond completion of COBRE funding.