MENTORING IN CARDIOVASCULAR BIOLOGY

描述(由申请人提供)：此次Cobre续签申请的总体目标是通过支持主题、多学科和多机构计划以及增强的基础设施能力，通过继续扩大和改进路易斯安那州立大学新奥尔良健康科学中心(LSUHSC-NO)的心血管研究，在上一次资助期间取得的成功的基础上再接再厉。通过这笔赠款提供的初始资金在LSUHSC-NO建立了一支才华横溢的心血管研究队伍，他们对 对心血管病理生理学的分子机制有基本的了解。通过强有力的领导、坚定的指导、与外部咨询委员会的互动关系和最先进的核心设施，我们已经实现了创纪录的职业发展，9名目标教员中有8名，5名NIH RO1资助，2名NIH R21资助，4名AHA基本助学金和2名科学家发展资助，以及2名教职员工赞助博士后和博士后奖学金(AHA和国防部)。 续签是在原有计划的基础上进行的，以实现一个更雄心勃勃的目标，即通过专注于转化性心血管研究的计划拨款申请，建立一个已建立的心血管卓越中心。为此，我们请求在此次续签申请中支持7-8名初级和有前途的发展中的研究人员的研究计划，他们将接受量身定做的一对一和团队指导，支持3个科学核心设施和1个行政核心，具有强大的商业行政和管理、教师发展和项目发展组成部分。此次Cobre更新的具体目标是：目标1。通过心血管疾病进展领域的研究计划，扩大LSUHSC-NO由NIH资助的研究人员的临界数量。目标2.加强现有和新的核心设施的基础设施和支助，这些设施将继续向有前途的初级和老牌调查人员提供最先进的研究资源。目的3.提供一个退出战略，以完成从科布雷支持的项目过渡到国家认可的跨学科翻译心血管卓越中心的智力基础和技术平台。这项提议将在基础和临床科学家之间为PPG、SCCOR和CTSA资助建立有效的科学合作，从而在完成Cobre资助后维持心血管中心。

DESCRIPTION (provided by applicant): The overall objectives for this COBRE renewal application is to build upon the successes accomplished during the previous funding period by continuing to expand and improve Cardiovascular Research at the Louisiana State University Health Sciences center-New Orleans(LSUHSC-NO) through support of thematic, multi-disciplinary and multi-institutional programs and enhanced infrastructure capabilities. The initial funding through this grant established a cadre of talented cardiovascular researchers at LSUHSC-NO that have made significant contributions to the basic understanding of molecular mechanisms that underlie cardiovascular pathophysiology. Through the strong leadership, committed mentoring, an interactive relationship with the External Advisory Committee and state-of-the-art Core facilities, we have achieved a record career advancement of 8 of 9 targeted faculty members, 5 NIH RO1 grants, 2 NIH R21 grants, 4 AHA Basic Grant- In-Aid and 2 Scientist Development Grants, and 2 faculty members sponsored Pre- and Postdoctoral Fellow Grant awards (AHA and Department of Defense). The renewal builds upon strength of the original program to achieve a more ambitious goal of an established Cardiovascular Center of Excellence though program grant applications focusing on translational cardiovascular research. To this end, we are requesting support in this renewal application for the research programs of 7-8 junior and promising developing investigators who will receive tailored one-on-one and team mentoring, the support for 3 scientific Core facilities and 1 administrative core that has strong business administration and management, faculty members development, and program development components. The Specific Aims of this COBRE renewal are: Aim 1. To expand the critical mass of NIH funded investigators at the LSUHSC-NO with research programs in the area of cardiovascular disease progression. Aim 2. To enhance the infrastructure and support of existing and new core facilities that will continue to provide state-of-the-art research resources to promising junior and established investigators. Aim 3. To provide an exit strategy that will complete the intellectual foundation and technological platform to transition from a COBRE supported project to a nationally recognized, interdisciplinary translational Cardiovascular Center of Excellence. This proposal will build effective scientific collaborations between basic and clinician scientists for PPG, SCCOR and CTSA funding that will sustain the Cardiovascular Center beyond completion of COBRE funding.