Modulation of endosomes for pathogen invasion

调节病原体入侵的内体

• 批准号: nhmrc : 569648
• 负责人: A/Pr Rohan Teasdale
• 金额: $ 32.71万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulation-endosomes-pathogen-invasion/97036
• 关键词: Modulation; endosomes; pathogen; invasion

Infectious pathogens invade cells by hijacking cellular pathways, termed endocytosis, that normally internalise material from outside the cell. We will identify the molecular details of these pathways and how they are modulated in response to infection with Salmonella, a leading cause of human gastroenteritis. Such studies are necessary in order to understand host-pathogen interactions so that treatments can be developed targeting the symptoms of infection

传染性病原体通过劫持细胞途径（称为内吞作用）侵入细胞，这种途径通常将细胞外的物质内化。我们将确定这些途径的分子细节，以及如何调节它们以应对沙门氏菌感染，沙门氏菌是人类胃肠炎的主要原因。为了了解宿主与病原体的相互作用，以便开发针对感染症状的治疗方法，此类研究是必要的