Unravelling the mechanism coupling synaptic activity with neurotrophin signaling in the nervous system

揭示神经系统中突触活动与神经营养素信号传导的耦合机制

• 批准号: nhmrc : GNT1120381
• 负责人: A/Pr Rohan Teasdale
• 金额: $ 64.08万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unravelling-mechanism-coupling-signaling-nervous/1347130
• 关键词: Unravelling; mechanism; coupling; synaptic; activity

Although active brain cells are known to survive for much longer than inactive ones, the mechanism underpinning this essential process has remained elusive. We have uncovered a direct coupling between neuronal activity and survival signals. The purpose of this grant application is to establish the molecular mechanism underpinning this coupling and understand how neuropathic pathogens manage to harness it with devastating effects to the brain.

尽管活跃的脑细胞比不活跃的脑细胞存活时间长得多，但支撑这一重要过程的机制仍然难以捉摸。我们已经发现了神经元活动和生存信号之间的直接耦合。这项拨款申请的目的是建立支持这种耦合的分子机制，并了解神经病病原体如何设法利用它对大脑产生破坏性影响。