The cell biology of macropinocytosis pathways in antigen presenting cells

抗原呈递细胞巨胞饮途径的细胞生物学

• 批准号: nhmrc : 566727
• 负责人: A/Pr Rohan Teasdale
• 金额: $ 36.36万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-biology-macropinocytosis-presenting-cells/101445
• 关键词: cell; biology; macropinocytosis; pathways; antigen

Cells internalise molecules in membrane-bound vesicles, a process known as endocytosis. This internalisation pathway is essential for many biological events, including the ability to capture foreign antigens and mount an effective immune response. Some internalisation pathways can be switched on by signals received at the cell surface. This study will identify the molecules that control antigen capture in immune cells. This knowledge is important for the development of better vaccines.

细胞将膜结合囊泡中的分子内化，这一过程称为内吞作用。这种内化途径对于许多生物事件至关重要，包括捕获外来抗原和发起有效免疫反应的能力。一些内化途径可以通过细胞表面接收到的信号来开启。这项研究将鉴定控制免疫细胞中抗原捕获的分子。这些知识对于开发更好的疫苗非常重要。