REACH-OUT

伸手

• 批准号: 7604746
• 负责人: DEBORAH BURNET
• 金额: $ 3.23万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604746
• 关键词: Adult; African American; Age; Area Under Curve; Behavior Therapy; Body Weight decreased; Body fat; Body mass index; Caring; Chicago; Child; Clinical; Communities; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Diabetes Mellitus; Diabetes prevention; Eating; Exercise; Family; Family history of; Fasting; Funding; Glucose; Grant; Habits; Hour; Incidence; Institution; Insulin; Intervention; Life Style; Measures; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Outcome Measure; Overweight; Parents; Pattern; Physical activity; Population; Population Study; Randomized; Recruitment Activity; Research; Research Personnel; Resources; Risk; Risk Factors; Source; Standards of Weights and Measures; United States National Institutes of Health; Weight Gain; Youth; base; design; diabetes risk; instrument; modifiable risk; nutrition; obesity risk; prevent; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obesity is increasing dramatically in young people, and with it the incidence of type 2 diabetes. This trend is especially pronounced among African Americans. About 16% of young people with new onset diabetes are found to have type 2 diabetes; among African-American youth in Chicago the proportion is 28%. As obesity is the major modifiable risk factor for type 2 diabetes, this diabetes prevention trial focuses on decreasing obesity (promoting weight loss/preventing weight gain, increasing activity, and changing eating patterns) in order to decrease risk for type 2 diabetes. Study Question: Can a culturally sensitive, community-based, family oriented intervention to decrease obesity and risk of type 2 diabetes in a high risk, urban, African-American population succeed? Design: We will recruit a total of 190 African American families (29 in pilot) known to be at high risk for diabetes. Families are randomized to high intensity behavioral intervention or standard care (control) groups. The intervention group participates in 14 weekly nutrition and exercise sessions. Subjects are followed for clinical outcomes for two years. Study Population: The study population is overweight (>85% BMI z-score) African American children between the ages of 9-12 with a family history of type 2 diabetes and accompanied by a parent/guardian. Primary outcome measure include BMI z-score, BMI (for adults), fasting glucose to insulin ratio, area under the curve (2 hour GTT), and body fat. Secondary outcomes include nutrition habits and lifestyle habits as measured by physical activity and nutrition instruments.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 年轻人和2型糖尿病的发生率的肥胖急剧增加。 在非裔美国人中，这种趋势尤其明显。 大约16％的新发作糖尿病患者患有2型糖尿病。在芝加哥的非裔美国人青年中，该比例为28％。 由于肥胖是2型糖尿病的主要可修改风险因素，因此该糖尿病预防试验的重点是减少肥胖症（促进体重减轻/预防体重增加，增加活动和改变饮食模式），以减少2型糖尿病风险。 研究问题：以文化敏感的，基于社区的，面向家庭的干预措施可以降低高风险中2型糖尿病的肥胖和风险，城市，非裔美国人人口成功吗？ 设计：我们将招募共有190个非洲裔美国家庭（29名飞行员），该家庭患有糖尿病的高风险。 家庭被随机分配到高强度行为干预或标准护理（对照）组。干预小组参加了14个每周营养和运动课程。 遵循两年的临床结果的受试者。 研究人群：研究人群超重（> 85％的BMI Z分数）非洲裔美国儿童在9-12岁之间，患有2型糖尿病的家族史，并由父母/监护人伴随。 主要结局指标包括BMI Z分数，BMI（用于成人），禁食葡萄糖与胰岛素比，曲线下的面积（2小时GTT）和体内脂肪。次要结果包括通过体育锻炼和营养仪器来衡量的营养习惯和生活方式习惯。