SURFACTANT POSITIVE AIRWAY PRESSURE AND PULSE OXIMETRY TRIAL (SUPPORT)

表面活性剂气道正压和脉搏血氧饱和度试验（支持）

• 批准号: 7604915
• 负责人: EDWARD F BELL
• 金额: $ 0.27万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604915
• 关键词: Admission activity; Age; Birth; Cessation of life; Chronic lung disease; Computer Retrieval of Information on Scientific Projects Database; Continuous Positive Airway Pressure; Delivery Rooms; Educational process of instructing; Environmental air flow; Extremely Low Birth Weight Infant; Funding; Grant; Incidence; Infant; Institution; Intervention; Intubation; Mechanical ventilation; Nature; Numbers; Outcome; Oxygen; Prospective Studies; Pulse Oximetry; Pulse Pressure; Randomized; Recommendation; Research; Research Personnel; Resources; Resuscitation; Severity of illness; Source; Standards of Weights and Measures; Supplementation; Time; United States National Institutes of Health; Week; day; improved; mortality; prophylactic; surfactant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. At the present time there is no recommendation or standard teaching regarding the early use of CPAP/PEEP during resuscitation and continuing after NICU admission for the extremely low birth weight (ELBW) infant. However, a number of studies, mostly retrospective in nature, have suggested that the use of early CPAP may be associated with improved outcomes, including a decreased need for mechanical ventilation, a decreased need for surfactant therapy, and a decrease in oxygen supplementation and/or death at 28 days after birth and at 36 weeks post menstrual age. There has not been a prospective study which has randomized ELBW infants to CPAP/PEEP beginning in the delivery room, and continuing in the NICU and a permissive ventilation strategy if intubation is required and compared their outcomes to infants treated with prophylactic or early natural surfactant, interventions with known efficacy in reducing mortality, severity of disease and the incidence of chronic lung disease.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目前，对于极低出生体重（ELBW）婴儿，在复苏期间早期使用CPAP/PEEP以及在NICU入院后继续使用CPAP/PEEP，没有推荐或标准教学。 然而，许多研究（大多数为回顾性研究）表明，早期使用CPAP可能与改善结局相关，包括对机械通气的需求减少，对表面活性剂治疗的需求减少，以及出生后28天和月经后36周的氧气补充和/或死亡减少。 目前还没有一项前瞻性研究将ELBW婴儿随机分配至CPAP/PEEP组，从产房开始，在NICU继续，如果需要插管，则采用允许通气策略，并将其结局与接受预防性或早期天然表面活性剂治疗的婴儿进行比较，这些干预措施在降低死亡率、疾病严重程度和慢性肺部疾病发生率方面具有已知疗效。