PROCALCITONIN, INTERLEUKIN-10, AND CD64 AS MARKERS OF NEONATAL SEPSIS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 细菌性脓毒症仍然是新生儿，特别是低出生体重儿发病和死亡的主要原因。 4%的产后3天内死亡和45%的死亡与感染有关，过去15年来这种模式没有变化。 细菌性败血症发生在1%至10%的足月新生儿中，在出生体重<800 g的婴儿中高达50倍。 工作目标：评价降钙素原、IL-10、CD 64和C-反应蛋白在新生儿败血症早期诊断中的作用，并确定每种标志物的最佳临界值。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Bacterial sepsis continues to be a major cause of morbidity and mortality in newborns, particularly in low-birth-weight infants. Four percent of deaths in the first 3 days of postnatal life and 45% of deaths are related to infections, with no change in this pattern for the last 15 years. Bacterial sepsis occurs in 1% to 10% of term newborns and is up to 50 times more common in infants with a birth weight <800 g. Aim of the work: to evaluate markers, namely Procalcitonin, IL-10, CD 64, and C-reactive protein for early diagnosis of neonatal sepsis and to identify the optimal cut off value of each marker.