INTEGRATED TRAINING FOR PHYSICIAN-SCIENTISTS

描述（由申请人提供）：我们正在申请威斯康星大学麦迪逊分校医学科学培训计划（MSTP）的持续资助。MSTP在其使命方面取得了重大进展，为医生科学家提供杰出的综合培训。形成该计划的核心理念是：(1)医学博士和博士的严格程度和水平应与单一学位候选人的培训相当；(2)学生相互学习；(3)毕业生将从事翻译研究，尽管程度不同。三名从事科研、研究生培训和临床活动的医生科学家领导MSTP。学生组织与主管们密切合作。MSTP指导委员会包括来自大学主要学院和学校的教师，并确保MSTP利用威斯康星大学麦迪逊分校学生可获得的广泛培训机会。通常学生在医学院接受临床前阶段的培训，同时在四个学期的研讨会/期刊俱乐部课程中熟悉研究方法，并参加研究轮转。第二年选择研究导师和研究生项目。临床衔接课程促进了研究生和医学工作之间的过渡，也向学生介绍了临床研究。医学院的主要临床课程是在完成博士论文后完成的。大多数学生的论文都是在传统的生物和化学科学方面需要加强训练的领域，但也有相当数量的学生正在研究基于人口的问题，以及工程和再生医学。再生医学项目利用小鼠和人（WA01和WA09）胚胎干细胞。学生产生大量的论文，导致重要的出版物。培养计划凝聚力的活动包括每周的研讨会、每年的静修、每年的专题讨论会和定期的社交聚会。为了拥有一个互动和充满活力的学生群体，我们的目标是每班10名学生，整体课程规模为70- 80名学生。我们的长期目标是培养一批对生物医学研究和临床医学实践有重大影响的多样化的医生科学家，因此，他们将成为学术医学的未来领导者。

DESCRIPTION (provided by applicant): We are requesting continued funding of the Medical Sciences Training Program (MSTP) at the University of Wisconsin-Madison. The MSTP has made significant progress in its mission to provide outstanding, integrated training to physician-scientists. Core philosophies that have shaped the Program are (1) the rigor and caliber of both the M.D. and the Ph.D. training should be equivalent to those of single degree candidates; (2) students learn from one another; and (3) graduates, albeit to variable degrees, will be engaged in translational research. Three physician-scientists, each of whom is active in research, graduate training, and clinical activities, direct the MSTP. A student organization works closely with the directors. Directors also are advised by the MSTP Steering Committee, which includes faculty from the major Colleges and Schools of the University and insures that the MSTP exploits the breadth of training opportunities available to students at UW-Madison. The usual student does the preclinical phase of Medical School training while Becoming acquainted with research methodologies in a four-semester seminar/journal club course and participating in research rotations. Research mentors and graduate programs are chosen in the second year. A clinical bridging curriculum facilitates the transitions between graduate and medical work and also introduces students to clinical research. The major clinical courses of Medical School are done after completion of the Ph.D. thesis. The majority of student theses are in areas that require strong training in the traditional biological and chemical sciences, but a significant number of students are doing research on population-based problems and in engineering and in regenerative medicine. The regenerative medicine projects utilize mouse and human (WA01 and WA09) embryonic stem cells. Students produce substantial theses that result in important publications. Activities that foster program cohesiveness include a weekly seminar, yearly retreat, yearly symposium, and regular social gatherings. To have an interactive and dynamic group of students, we are aiming for a class size of ten students for an overall program size of 70- 80 students. Our long-term goal is to train a diverse group of physician-scientists who will have major impact on biomedical research and the practice of clinical medicine, and hence, will be future leaders in Academic Medicine.