PRIMATE DECIDUA AND FETAL MEMBRANES AS A PARACRINE SYSTEM
灵长类蜕膜和胎膜作为旁分泌系统
基本信息
- 批准号:7715891
- 负责人:
- 金额:$ 1.11万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-05-01 至 2009-04-30
- 项目状态:已结题
- 来源:
- 关键词:BirthCharacteristicsComputer Retrieval of Information on Scientific Projects DatabaseDeciduaDevelopmentExtracellular MatrixFetal MembranesFundingGrantGrowthHumanInfectionInflammatory ResponseInstitutionLocalizedMediatingMediator of activation proteinModelingPathway interactionsPatient currently pregnantPatientsPremature BirthPremature Rupture Fetal MembranesPrimatesRecombinantsRelaxinResearchResearch PersonnelResourcesSourceSystemUnited States National Institutes of Healthnonhuman primateparacrine
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
In the absence of infection, a localized low-level inflammatory response in the fetal membrane may be associated with premature rupture of membranes (PROM) in both term and preterm birth. This contrasts with the florid inflammatory response characteristic of infection-mediated preterm parturition. Decidual relaxin expression is increased in patients with PROM and preterm birth. The objective of this research is to ascertain whether intraamniotic administration of human recombinant relaxin in a pregnant nonhuman primate model causes changes in key pathways (developmental growth regulators, extracellular matrix modulators, and/or proinflammatory mediators) which may precede preterm premature rupture of the fetal membranes (PPROM).
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
在没有感染的情况下,胎膜中的局部低水平炎症反应可能与足月和早产中的胎膜早破(PROM)有关。 这与感染介导的早产的特征性炎症反应形成对比。 胎膜早破和早产患者蜕膜松弛素表达增加 本研究的目的是确定在妊娠非人灵长类动物模型中羊膜内给予人重组松弛素是否会导致关键途径(发育生长调节剂、细胞外基质调节剂和/或促炎介质)的变化,这些变化可能发生在胎膜早破(PPROM)之前。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('MILES J. NOVY', 18)}}的其他基金
ORAL OXYTOCIN ANTAGONIST PHARMACODYNAMICS IN PREGNANT/NONPREGNANT RHESUS MONKEY
口服催产素拮抗剂在怀孕/非怀孕恒河猴中的药效学
- 批准号:
7715939 - 财政年份:2008
- 资助金额:
$ 1.11万 - 项目类别:
PRETERM LABOR AND FETAL SEQUELAE: ROLE OF MYCOPLASMAS
早产和胎儿后遗症:支原体的作用
- 批准号:
7715872 - 财政年份:2008
- 资助金额:
$ 1.11万 - 项目类别:
PRETERM LABOR AND FETAL SEQUELAE: ROLE OF MYCOPLASMAS
早产和胎儿后遗症:支原体的作用
- 批准号:
7561865 - 财政年份:2007
- 资助金额:
$ 1.11万 - 项目类别:
PRIMATE DECIDUA AND FETAL MEMBRANES AS A PARACRINE SYSTEM
灵长类蜕膜和胎膜作为旁分泌系统
- 批准号:
7561891 - 财政年份:2007
- 资助金额:
$ 1.11万 - 项目类别:
ORAL OXYTOCIN ANTAGONIST PHARMACODYNAMICS IN PREGNANT/NONPREGNANT RHESUS MONKEY
口服催产素拮抗剂在怀孕/非怀孕恒河猴中的药效学
- 批准号:
7561969 - 财政年份:2007
- 资助金额:
$ 1.11万 - 项目类别:
PRETERM LABOR AND FETAL SEQUELAE: ROLE OF MYCOPLASMAS
早产和胎儿后遗症:支原体的作用
- 批准号:
7348876 - 财政年份:2006
- 资助金额:
$ 1.11万 - 项目类别:
PRETERM LABOR AND FETAL SEQUELAE: ROLE OF MYCOPLASMAS
早产和胎儿后遗症:支原体的作用
- 批准号:
7165184 - 财政年份:2005
- 资助金额:
$ 1.11万 - 项目类别:
MATERNAL-FETAL-AMNIOTIC FLUID PHARMACOKINETICS OF IL-1RA AND UTERINE ACTIVITY
IL-1RA 的母体-胎儿-羊水药代动力学和子宫活性
- 批准号:
7165202 - 财政年份:2005
- 资助金额:
$ 1.11万 - 项目类别:
HUMAN DECIDUA AND FETAL MEMBRANES AS A PARACRINE SYSTEM
人类蜕膜和胎膜作为旁分泌系统
- 批准号:
7165226 - 财政年份:2005
- 资助金额:
$ 1.11万 - 项目类别:
MATERNAL-FETAL-AMNIOTIC FLUID PHARMACOKINETICS OF IL-1RA AND UTERINE ACTIVITY
IL-1RA 的母体-胎儿-羊水药代动力学和子宫活性
- 批准号:
6970639 - 财政年份:2004
- 资助金额:
$ 1.11万 - 项目类别:
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