Modulation of TGF-beta signaling by CDA1 in the diabetic vasculature

CDA1 对糖尿病血管系统中 TGF-β 信号传导的调节

• 批准号: nhmrc : 1028078
• 负责人: A/Pr Terri Allen
• 金额: $ 34.94万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modulation-tgf-beta-diabetic-vasculature/110612
• 关键词: Modulation; TGF; beta; signaling; CDA1

Cell Division Autoantigen 1 (CDA1) is a molecule we identified several years ago. Recently we found that CDA1 played an unique role in causing blood vessels to scar and become stiff by hijacking and controlling the existing transforming growth factor-beta (TGF-beta) signaling pathway. We will explore the possibility to use this unique property of CDA1 to treat the blood vessel hardening and related diseases such as atherosclerosis and heart attacks, particularly in the setting of diabetes.

细胞分裂自身抗原1（CDA 1）是我们几年前发现的一种分子。最近，我们发现CDA 1通过劫持和控制现有的转化生长因子-β（TGF-β）信号通路，在导致血管瘢痕和变得僵硬方面发挥了独特的作用。我们将探索利用CDA 1的这种独特性质来治疗血管硬化和相关疾病的可能性，如动脉粥样硬化和心脏病发作，特别是在糖尿病的情况下。