Role of the podocyte in diabetic nephropathy: Structural, functional, molecular and interventional studies

足细胞在糖尿病肾病中的作用：结构、功能、分子和介入研究

• 批准号: nhmrc : 145773
• 负责人: A/Pr Terri Allen
• 金额: $ 15.14万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-podocyte-diabetic-interventional-studies/95820
• 关键词: Role; podocyte; diabetic; nephropathy; Structural

Kidney disease is a major cause of disability and premature death in the Australian population. In disease the kidney's ability to filter out impurities and toxins in blood is impaired as a consequence of excessive cell growth and scar tissue formation. Studies from our group indicate that a highly specialised cell within the kidney's filtering apparatus becomes altered early in the course of diabetes. In the setting of diabetes, this cell, called the podocyte, stretches and begins forming scar tissue. In addition, it no longer maintains its barrier function and starts to leak protein. The proposed studies will explore the mechanisms that lead to these diabetes-induced changes in the podocyte. In addition, strategies for reversing these changes will also be explored in detail with the aim of providing new treatments for diabetic kidney disease.

肾脏疾病是澳大利亚人口残疾和过早死亡的主要原因。在疾病中，由于细胞过度生长和疤痕组织的形成，肾脏过滤血液中杂质和毒素的能力受到损害。我们小组的研究表明，在糖尿病病程的早期，肾脏过滤装置中的一个高度专门化的细胞会发生变化。在糖尿病的情况下，这种被称为足细胞的细胞伸展并开始形成疤痕组织。此外，它不再维持其屏障功能，并开始泄漏蛋白质。拟议中的研究将探索导致这些糖尿病诱导的足细胞变化的机制。此外，还将详细探讨扭转这些变化的策略，以期为糖尿病肾病提供新的治疗方法。