The Role of Urotensin II in Diabetes-Associated Atherosclerosis

尾加压素 II 在糖尿病相关动脉粥样硬化中的作用

• 批准号: nhmrc : 586678
• 负责人: A/Pr Terri Allen
• 金额: $ 27.05万
• 依托单位: Baker IDI Heart and Diabetes Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-urotensin-ii-associated-atherosclerosis/76091
• 关键词: Role; Urotensin; II; Diabetes; Associated

People with diabetes most commonly die from stroke or heart attack and we need to determine what makes them more prone to these problems. The recently discovered UII system is increased in people with diabetes and has been found in diseased parts of blood vessels. Thus, the aim of this project is to characterise the UII system in the setting of diabetes using 2 unique genetically altered mice and a blocker a to study the effects of high cholesterol, diabetes and a deletion of UII.

糖尿病患者最常死于中风或心脏病，我们需要确定是什么让他们更容易出现这些问题。最近发现的 UII 系统在糖尿病患者中增加，并且在血管的病变部位也发现了这种系统。因此，该项目的目的是使用 2 只独特的基因改造小鼠和阻断剂 a 来表征糖尿病背景下的 UII 系统，以研究高胆固醇、糖尿病和 UII 缺失的影响。