Role of vasoactive hormones and cytokines in diabetic nephropathy

血管活性激素和细胞因子在糖尿病肾病中的作用

• 批准号: nhmrc : 209026
• 负责人: A/Pr Terri Allen
• 金额: $ 24.11万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-vasoactive-hormones-diabetic-nephropathy/96224
• 关键词: Role; vasoactive; hormones; cytokines; diabetic

Kidney disease is a major cause of disability and premature death in the Australian population. In diabetic kidney disease a major factor which accelerates the progression of this disorder is the presence of hypertension. Indeed international and national organisations now recommend aggressive blood pressure treatment in the diabetic patient. This proposal aims to optimise blood pressure treatment in diabetes and evaluate novel more potent blood pressure lowering agents which block within the kidney important hormonal pathways implicated in diabetic kidney disease. This approach will assist in determining key factors which mediate the damage to the kidney induced by elevated blood pressure. It is anticipated that these studies will lead to more rational, targeted and powerful antihypertensive agents which will retard or prevent the development of diabetic nephropathy.

肾脏疾病是澳大利亚人口残疾和过早死亡的主要原因。在糖尿病肾病中，高血压的存在是加速这种疾病进展的主要因素。事实上，国际和国家组织现在建议对糖尿病患者进行积极的血压治疗。该建议旨在优化糖尿病的血压治疗，并评估新的更有效的降压药，这些降压药可以阻断肾脏内与糖尿病肾病相关的重要激素通路。这种方法将有助于确定介导血压升高引起的肾脏损伤的关键因素。我们期待这些研究能带来更合理、更有针对性和更强效的抗高血压药物，从而延缓或预防糖尿病肾病的发生。