Molecular basis for female age-associated decline in oocyte quality and fertility

许多女性不能生育是因为卵子质量不理想，通常是由于衰老。为了开发提高卵子质量的新策略，首先重要的是了解卵子中的关键因素是如何调节的。这个项目将使用最先进的技术来研究我们在卵子中发现的一个关键途径，这个途径可能负责与年龄相关的衰退，并可能掌握使卵子恢复活力的新方法的关键。

Many women cannot have children because of suboptimal egg quality, often due to ageing. In order for novel strategies to be developed for improving egg quality, it will first be important to understand how key factors in eggs are regulated. This project will use state-of-the-art techniques to interrogate a pivotal pathway we have discovered in eggs that could be responsible for age-related decline and could hold the key to new approaches for rejuvenating eggs.