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Center for Environment and Mammary Gland Development

环境与乳腺发育中心

基本信息

批准号：
7668549
负责人：
JOSE RUSSO
金额：
$ 169.02万
依托单位：
FOX CHASE CANCER CENTER
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-29 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7668549
关键词：
Address Advisory Committees Advocate Age Alabama Basic Science Bioinformatics Child Development Clinical Communication Communities Community Outreach Comprehensive Cancer Center Educational workshop Environment Environmental Exposure Environmental Health Environmental Risk Factor Fox Chase Cancer Center Goals Grant Growth and Development function Institution Knowledge Language Leadership Learning Malignant Neoplasms Mission Names New York Newsletter Nutritionist Participant Patients Pennsylvania Philadelphia Policy Maker Population Predisposition Principal Investigator Puberty Publishing Research Research Personnel Research Project Grants Resources Role Site Translating Translations Universities Work anticancer research authority base cancer prevention clinical research site experience fitness girls innovation instructor malignant breast neoplasm mammary gland development medical schools meetings member news programs

项目摘要

The Fox Chase Cancer Center in Philadelphia, Pennsylvania, the University of Alabama Comprehensive Cancer Center in Birmingham, Alabama, and the Mount Sinai School of Medicine in New York, New York, have joined efforts for organizing a Breast Cancer and the Environment Research Center. Researchers at the three participating institutions have a long-lasting commitment to breast cancer research, demonstrated through pioneer work that has identified critical windows of susceptibility to carcinogenic and environmental exposures. The unique experience of this multi-institutional and multi-disciplinary group will provide a broad and comprehensive armarmentarium encompassing varied populations, clinical and basic sciences, and bioinformatics expertise that will be immediately translated to the population it will serve through carefully orchestrated programs under the guidance of patient advocates. The Breast Cancer and the Environment Research Center proposed here will be named Center for the Study of the Environment and Mammary Gland and Development. The Center is organized around two research projects, the Collaborative Project 1 (CP 1) and Collaborative Project 2 (CP 2), and two cores, the Administrative Core and the Community Outreach and Translation Core (COTC). The Administrative Core will serve as a liaison with the Steering Committee of the Breast Cancer and the Environment Research Center Consortium, the Breast Cancer and the Environment Task Force and the National Advisory Board. In addition, there will be an Executive Committee, which will be chaired by the Principal Investigator and will be integrated by the Co-Principal Investigators and one Cancer Advocate. The Executive Committee will receive advice from the Internal and the External Advisory Boards. The Executive Committee will meet on regular basis with the Co-PIs and investigators participating in CP 1 and CP 2, as well as with Members of the Administrative Core and the COTC. Consequently, the chain of authority for the Center grant will start from the Principal Investigator who will provide scientific leadership for all aspects of the Center. These lines of authority will not interfere with the internal chain of authority at each one of the participating institutions. The mission of the Center will be accomplished through interactive meetings among the participants of the Center, and other centers participating in this consortium.

位于宾夕法尼亚州费城的福克斯蔡斯癌症中心、位于阿拉巴马州伯明翰的阿拉巴马大学综合癌症中心和位于纽约州纽约的西奈山医学院共同努力组织了一个乳腺癌和环境研究中心。这三家参与机构的研究人员长期致力于乳腺癌研究，他们的先驱性工作已经确定了对致癌物和环境暴露的易感性的关键窗口。这个多机构、多学科小组的独特经验将提供一个广泛而全面的装备，包括不同的人群，临床和基础科学，以及生物信息学专业知识，这些知识将立即转化为它将在患者倡导者的指导下通过精心策划的项目服务的人群。在这里提议的乳腺癌和环境研究中心将被命名为环境与乳腺和发育研究中心。该中心围绕两个研究项目组织，合作项目1 （CP 1）和合作项目2 (CP 2)，以及两个核心，行政核心和社区外展和翻译核心（COTC）。行政核心将与乳腺癌和环境研究中心联合会指导委员会、乳腺癌和环境工作队以及国家咨询委员会进行联络。此外，还将成立一个执行委员会，由首席研究员担任主席，并由联合首席研究员和一名癌症倡导者参与。执行委员会将接受内部和外部咨询委员会的建议。执行委员会将定期与参与方案1和方案2的共同调查专员和调查人员，以及行政核心和反恐委员会的成员举行会议。因此，中心拨款的权力链将从首席研究员开始，他将为中心的各个方面提供科学领导。这些权力线不会干扰每个参与机构的内部权力链。中心的使命将通过中心参与者和其他参与该联盟的中心之间的互动会议来完成。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The plasticizer butyl benzyl phthalate induces genomic changes in rat mammary gland after neonatal/prepubertal exposure.

DOI：
10.1186/1471-2164-8-453
发表时间：
2007-12-06
期刊：
BMC GENOMICS
影响因子：
4.4
作者：
Moral, Raquel;Wang, Richard;Russo, Irma H;Mailo, Daniel A;Lamartiniere, Coral A;Russo, Jose
通讯作者：
Russo, Jose

Estrogen and xenoestrogens in breast cancer.