Small Animal Imaging

基于分子的成像提供了新的机会，以评估体内重要的细胞过程。的能力 通过非侵入性成像监测癌症的分子过程可以提供关键信息， 关于治疗的效果在临床前研究的背景下，体内成像的使用使得能够在体内成像。 在每只动物中进行完整的动态生物分布研究，从而减少 需要达到统计学上充分结果的动物;通常用于小动物成像的技术 可直接应用于临床。小动物成像核心（SAIC）是一个新的共享 致力于为研究者提供最先进的小动物成像技术的资源 用于与希望之城癌症使命相关的基础和转化研究的能力 中心SAIC的具体目标包括：（1）保持对当前 与癌症研究有关的小动物成像的能力和局限性;（2）实施， 开发，校准，维护和操作相关的成像系统在一个小的背景下， 动物成像实验室;以及（3）优化希望之城研究中小动物成像的使用， 与调查人员协商。核心人员目前包括一名主任、一名成像物理学家和一名 经理，他们都是非常有经验的使用成像的研究与动物。小动物 操作中的成像系统包括用于生物发光光学成像的两个单元（I维斯100，Xenogen Corp.）;伽马照相机（Y IMAGER，Biospace，Inc.）; PET扫描仪（microPET R4，CTIMI，Inc.）;和CT 扫描仪（microCAT II Hi Res，CTIMI，Inc.）。microPET和microCAT易于串联使用， 生成共配准的功能-解剖PET/CT图像。动物资源中心提供 Parvin生物医学研究大楼内的四个房间，供动物成像程序使用（一个房间 用于microPET、microCAT和y-IMAGER的两个房间;用于Xenogen MS机器的两个房间;以及用于 对于伽马计数器）。已经开发了一个系统，用于向用户收取部分成像费用 程序.在前12个月报告期间，13名癌症中心成员使用了SAIC 来自3个研究项目和同行评审的使用量占总使用量的89%。年度预算 核心费用为165，922美元（97%为机构费用，3%为退款）; 42%（70，000美元）的费用由CCSG提供。

Molecular-based imaging provides new opportunities to assess vital cellular processes in vivo. The ability to monitor the molecular processes of cancer via non-invasive imaging may provide critical information regarding the effects of therapy. In the context of pre-clinical research, the use of in vivo imaging permits the acquisition of a complete dynamic biodistribution study in each animal, thereby reducing the number of animals required to reach a statistically adequate result; often the techniques used in small animal imaging are directly transferable to the clinical setting. The Small Animal Imaging Core (SAIC) is a new shared resource dedicated to providing investigators access to the state-of-the-art in small animal imaging capabilities for use in basic and translational research relevant to the mission of the City of Hope Cancer Center. Specific aims of the SAIC include: (1) maintaining a thorough understanding of the current capabilities and limitations of small animal imaging as they pertain to cancer research; (2) implementing, developing, calibrating, maintaining, and operating relevant imaging systems within the context of a small animal imaging laboratory; and (3) optimizing the use of small animal imaging in research at City of Hope by consulting with investigators. Core personnel currently include a Director, an imaging physicist, and a manager, all of whom are highly experienced in the use of imaging for research with animals. Small animal imaging systems in operation include two units for bioluminescence optical imaging (I VIS 100, Xenogen Corp.); a gamma camera (Y IMAGER, Biospace, Inc.); a PET scanner (microPET R4, CTIMI, Inc.); and a CT scanner (microCAT II Hi Res, CTIMI, Inc.). The microPET and microCAT are readily used in tandem to generate co-registered functional-anatomic PET/CT images. The Animal Resources Center has provided four rooms within the Parvin Biomedical Research Building for use by the animal imaging program (one room for the microPET, microCAT, and the y-IMAGER; two rooms for the Xenogen MS machines; and one room for a gamma counter). A system has been developed for billing users for a portion of the costs of the imaging procedures. During the first 12-month reporting period, the SAIC was used by 13 Cancer Center members from 3 Research Programs and peer-reviewed usage represented 89% of total usage. Annual budget for the core is $165,922 (97% institution, 3% chargebacks); 42% ($70,000) is being requested from the CCSG.