Developmental Funds

发展基金

• 批准号: 7714113
• 负责人: THEODORE G KRONTIRIS
• 金额: $ 17.73万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714113
• 关键词: Area; Award; Biopolymers; Budgets; Cancer Center; Cancer Center Support Grant; Capital; Chemistry; Chest; Cities; City of Hope Comprehensive Cancer Center; Clinical; Clinical Trials; Collaborations; Correlative Study; Data; Development; Disease; Equipment; Evolution; Funding; Future; Goals; Grant; Growth; Housing; Immunobiology; Institution; Laboratories; Leadership; Lymphoma; Malignant Neoplasms; Molecular; Pilot Projects; Population Sciences; Process; Prostate; Regulation; Reproduction spores; Research; Research Activity; Research Infrastructure; Research Personnel; Research Subjects; Resource Sharing; Resources; Risk; Safety; Speed; Structure-Activity Relationship; Surveys; Translational Research; Wages; Work; anticancer research; concept; cost; density; high throughput screening; innovation; member; preference; programs; small molecule; therapeutic target

In the past funding period, the City of Hope Comprehensive Cancer Center distributed awards for 12 pilot projects in the amount of $485,000 to encourage collaborative projects or high-risk research of Center members. Grants exceeding $2,800,000 resulted from several of these collaborations, including one project grant of our new lymphoma SPORE and several R01s. The Center also provided $100,000 over 2 years in support of the developing core, Clinical Immunobiology Correlative Studies Laboratory, which is a new shared resource in this renewal application. During the next funding period, the COHCCC has undertaken an ambitious goal: to accelerate its translational research activities through recruitment and program and infrastructure development so that we increase¿with speed, safety, and effectiveness¿the density of innovative laboratory discoveries reaching in-house clinical trials. We propose to use our developmental funds, a requested total of $250,000 yearly, to support programmatic growth as follows: ¿ $100,000 yearly for 2 to 3 projects focused in the three clinical programs¿breast, prostate, and thoracic malignancies¿that we have targeted for evolution into Center research programs on the occasion of the next CCSG renewal. ¿ Each project to pair a clinical and laboratory researcher in the disease area We will advance our infrastructure by developing three new shared resources: ¿ High Throughput Screening to identify small molecular modulators of cancer therapeutics targets identified by Center investigators ($50,000/year for 3 years) ¿ Synthetic and Biopolvmer Chemistry to pursue small-molecule structure/activity relationships ($50,000/year for 3 years) ¿ Survey Research to assist our population sciences investigators in gathering data from dispersed research subjects in an efficient process that is compliant with institutional and governmental regulations ($50,000/year for 3 years)

在刚刚过去的资助期内，希望之城综合肿瘤中心为12名试点发放了奖励 48.5万美元的项目，以鼓励合作项目或中心的高风险研究 成员其中几项合作，包括一个项目，产生了超过2 800 000美元的赠款 我们新的淋巴瘤孢子和几个R 01的赠款。该中心还在两年内提供了10万美元， 支持发展核心，临床免疫生物学相关研究实验室，这是一个新的 在此更新应用程序中共享资源。在下一个资助期内，委员会已承诺 一个雄心勃勃的目标：通过招聘和计划加速其转化研究活动， 基础设施的发展，使我们增加速度，安全性和有效性的密度， 创新的实验室发现达到内部临床试验。我们建议利用我们的发展 a要求每年提供总额为250 000美元的资金，用于支持方案增长，具体如下： 每年10万美元用于2至3个项目，重点是三个临床项目：乳腺，前列腺和 胸部恶性肿瘤，我们有针对性地演变成中心的研究计划， 下一次CCSG更新的时机。 每个项目将疾病领域的临床和实验室研究人员配对 我们将通过开发三种新的共享资源来推进我们的基础设施： 高通量筛选以确定癌症治疗靶点的小分子调节剂 由中心研究者确定（5万美元/年，3年） 合成和生物聚合物化学追求小分子结构/活性关系 （3年，每年50 000美元） 调查研究，以协助我们的人口科学调查人员收集数据，从分散的 研究主题在一个有效的过程，是符合机构和政府 条例（3年，每年50 000美元）