Developmental Funds

发展基金

• 批准号: 7714113
• 负责人: THEODORE G KRONTIRIS
• 金额: $ 17.73万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714113
• 关键词: Area; Award; Biopolymers; Budgets; Cancer Center; Cancer Center Support Grant; Capital; Chemistry; Chest; Cities; City of Hope Comprehensive Cancer Center; Clinical; Clinical Trials; Collaborations; Correlative Study; Data; Development; Disease; Equipment; Evolution; Funding; Future; Goals; Grant; Growth; Housing; Immunobiology; Institution; Laboratories; Leadership; Lymphoma; Malignant Neoplasms; Molecular; Pilot Projects; Population Sciences; Process; Prostate; Regulation; Reproduction spores; Research; Research Activity; Research Infrastructure; Research Personnel; Research Subjects; Resource Sharing; Resources; Risk; Safety; Speed; Structure-Activity Relationship; Surveys; Translational Research; Wages; Work; anticancer research; concept; cost; density; high throughput screening; innovation; member; preference; programs; small molecule; therapeutic target

In the past funding period, the City of Hope Comprehensive Cancer Center distributed awards for 12 pilot projects in the amount of $485,000 to encourage collaborative projects or high-risk research of Center members. Grants exceeding $2,800,000 resulted from several of these collaborations, including one project grant of our new lymphoma SPORE and several R01s. The Center also provided $100,000 over 2 years in support of the developing core, Clinical Immunobiology Correlative Studies Laboratory, which is a new shared resource in this renewal application. During the next funding period, the COHCCC has undertaken an ambitious goal: to accelerate its translational research activities through recruitment and program and infrastructure development so that we increase¿with speed, safety, and effectiveness¿the density of innovative laboratory discoveries reaching in-house clinical trials. We propose to use our developmental funds, a requested total of $250,000 yearly, to support programmatic growth as follows: ¿ $100,000 yearly for 2 to 3 projects focused in the three clinical programs¿breast, prostate, and thoracic malignancies¿that we have targeted for evolution into Center research programs on the occasion of the next CCSG renewal. ¿ Each project to pair a clinical and laboratory researcher in the disease area We will advance our infrastructure by developing three new shared resources: ¿ High Throughput Screening to identify small molecular modulators of cancer therapeutics targets identified by Center investigators ($50,000/year for 3 years) ¿ Synthetic and Biopolvmer Chemistry to pursue small-molecule structure/activity relationships ($50,000/year for 3 years) ¿ Survey Research to assist our population sciences investigators in gathering data from dispersed research subjects in an efficient process that is compliant with institutional and governmental regulations ($50,000/year for 3 years)

在过去的资助期内，希望之城综合癌症中心为12个试点项目发放了奖励