Effect of coinheritance on host-pathogen coevolution

共同遗传对宿主-病原体协同进化的影响

基本信息

  • 批准号:
    7688520
  • 负责人:
  • 金额:
    $ 21.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-09-15 至 2011-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The overall goal of the proposed research is to develop the genetic theory necessary for understanding how patterns of co-transmission of host and microbial genomes affect the co-evolution of symbiotic and pathogenic bacteria with their hosts. Our approach is novel in that it extends theory developed for modeling the inheritance of nuclear gene combinations within single genomes to gene combinations across two genomes, those of host and pathogen. When applied to nuclear and mitochondrial gene combinations, this approach successfully predicted the frequency of functional gene transfer from the mitochondria to the nucleus: inter-genomic transfer of functional genes is ten-fold more likely to occur in inbreeding species than in outcrossing species. The reason for this effect of mating system on gene transfer is that mating systems, where mitochondrial and nuclear genes are inherited together, allow natural selection to act more effectively on gene combinations than mating systems where the genes are inherited independently. Although mitochondria are wholly vertically transmitted like some endosymbionts, similar effects are expected to be manifest in systems with only partial vertical transmission and we will develop this more general theory. Two-locus descent theory quantifies the coinheritance of gene combinations in the same or different genomes, determining the degree to which the evolutionary trajectories of genes in each species are conjoined. This determines whether a host-pathogen association will develop toward enhanced virulence or toward benign symbiosis. Project Narrative: Change in the dispersal rates fundamentally change the genetic coevolution both hosts and their pathogens and contribute to the emergence of new diseases. Although a direct link between dispersal of infected hosts and disease epidemiology within a single host generation is well known, the genetic consequences of disease transmission from one generation of hosts to the next is much more poorly understood. This proposal will develop genetic theory for addressing how the co-inheritance of host genes and host pathogens affects the evolution of disease virulence.
描述(由申请人提供):拟议研究的总体目标是发展必要的遗传学理论,以了解宿主和微生物基因组的共同传播模式如何影响共生细菌和致病菌与宿主的共同进化。我们的方法是新颖的,因为它扩展了为单基因组内核基因组合遗传建模的理论,以跨两个基因组(宿主和病原体的基因组)的基因组合。当应用于细胞核和线粒体基因组合时,该方法成功地预测了功能基因从线粒体转移到细胞核的频率:功能基因的基因组间转移在近交物种中发生的可能性是异交物种的十倍。交配系统对基因转移产生这种影响的原因是,与基因独立遗传的交配系统相比,线粒体和核基因一起遗传的交配系统允许自然选择更有效地作用于基因组合。虽然线粒体像一些内共生体一样完全垂直传播,但在只有部分垂直传播的系统中预计也会出现类似的效果,我们将发展这一更普遍的理论。双位点遗传理论量化了相同或不同基因组中基因组合的共遗传,确定了每个物种中基因进化轨迹的结合程度。这决定了宿主-病原体关联是否会朝着增强毒力或良性共生的方向发展。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Michael J Wade其他文献

Natural Course of Co-Occurring PTSD and Alcohol Use Disorder Among Recent Combat Veterans.
最近的退伍军人中同时发生创伤后应激障碍和酒精使用障碍的自然过程。
  • DOI:
    10.1002/jts.22192
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Kyle Possemato;S. Maisto;Michael J Wade;Kimberly Barrie;Emily M Johnson;P. Ouimette
  • 通讯作者:
    P. Ouimette
Health Service and Medication Use Among Veterans With Persistent Postconcussive Symptoms
患有持续性脑震荡后症状的退伍军人的健康服务和药物使用
Current prescribing patterns in outpatient child and adolescent psychiatric practice in central New York.
纽约中部门诊儿童和青少年精神病学实践的当前处方模式。
Validation of an Expanded Measure of Integrated Care Provider Fidelity: PPAQ-2
综合护理提供者忠诚度扩展衡量标准的验证:PPAQ-2
  • DOI:
    10.1007/s10880-019-09628-0
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    G. Beehler;J. Funderburk;P. King;Kyle Possemato;John Maddoux;Wade R. Goldstein;Michael J Wade
  • 通讯作者:
    Michael J Wade
Online Problem-Solving Training with and without Peer Support in Veterans with Unmet Mental Health Needs: A Pilot Study of Feasibility, User Acceptability and Patient Engagement (Preprint)
对心理健康需求未得到满足的退伍军人进行有或没有同伴支持的在线问题解决培训:可行性、用户可接受性和患者参与度的试点研究(预印本)
  • DOI:
    10.2196/preprints.29559
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Kyle Possemato;Justina Wu;Carolyn J. Greene;Rex MacQueen;D. Blonigen;Michael J Wade;J. Owen;Terrence M. Keane;D. Brief;S. Lindley;A. Prins;M. Mackintosh;E. Carlson
  • 通讯作者:
    E. Carlson

Michael J Wade的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Michael J Wade', 18)}}的其他基金

Effect of coinheritance on host-pathogen coevolution
共同遗传对宿主-病原体协同进化的影响
  • 批准号:
    7901491
  • 财政年份:
    2008
  • 资助金额:
    $ 21.56万
  • 项目类别:
The effect of coinheritance on host-symbiont coevolution
共遗传对宿主-共生体协同进化的影响
  • 批准号:
    8291752
  • 财政年份:
    2008
  • 资助金额:
    $ 21.56万
  • 项目类别:
The effect of coinheritance on host-symbiont coevolution
共遗传对宿主-共生体协同进化的影响
  • 批准号:
    8449295
  • 财政年份:
    2008
  • 资助金额:
    $ 21.56万
  • 项目类别:
Effect of coinheritance on host-pathogen coevolution
共同遗传对宿主-病原体协同进化的影响
  • 批准号:
    7445552
  • 财政年份:
    2008
  • 资助金额:
    $ 21.56万
  • 项目类别:
The effect of coinheritance on host-symbiont coevolution
共遗传对宿主-共生体协同进化的影响
  • 批准号:
    8610927
  • 财政年份:
    2008
  • 资助金额:
    $ 21.56万
  • 项目类别:
Epistasis: Its role in complex traits and speciation
上位性:其在复杂性状和物种形成中的作用
  • 批准号:
    6885412
  • 财政年份:
    2003
  • 资助金额:
    $ 21.56万
  • 项目类别:
Epistasis: Its role in complex traits and speciation
上位性:其在复杂性状和物种形成中的作用
  • 批准号:
    7058825
  • 财政年份:
    2003
  • 资助金额:
    $ 21.56万
  • 项目类别:
Epistasis: Its role in complex traits and speciation
上位性:其在复杂性状和物种形成中的作用
  • 批准号:
    6606374
  • 财政年份:
    2003
  • 资助金额:
    $ 21.56万
  • 项目类别:
Epistasis: Its role in complex traits and speciation
上位性:其在复杂性状和物种形成中的作用
  • 批准号:
    6742416
  • 财政年份:
    2003
  • 资助金额:
    $ 21.56万
  • 项目类别:
GENETICS OF CYTOPLASMIC INCOMPATIBILITY
细胞质不相容性的遗传学
  • 批准号:
    6107690
  • 财政年份:
    1998
  • 资助金额:
    $ 21.56万
  • 项目类别:

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 21.56万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 21.56万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 21.56万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 21.56万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 21.56万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 21.56万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 21.56万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 21.56万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 21.56万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 21.56万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了