Molecular determinants of UDP glucuronosyltransferase 1A3 and 1A4 expression

肝脏和胃肠道中的酶在保护免受脂溶性化学物质的毒性作用方面起着至关重要的作用。其中两种称为UGT1A3和UGT1A4的酶在保护免受含有氮基团的药物和毒素侵害方面具有特殊作用。这两种酶在肝脏和肠道中的水平在个体之间差异很大。在这个项目中，我们将确定这些酶的水平是如何控制的，以及个体之间这种差异的原因是什么。这将有助于我们预测那些更容易受到含氮药物不良影响和饮食或环境中化学物质毒性影响的人。该项目还将帮助我们开发提高这些保护酶水平的方法，并帮助减少接触有毒化学物质的影响。

Enzymes in the liver and gastrointestinal tract have a crucial role in protecting against the toxic effects of fat-soluble chemicals. Two of these enzymes called UGT1A3 and UGT1A4 have a special role in protecting against drugs and toxins that contain nitrogen groups. The levels of these two enzymes in the liver and gut vary extensively between individuals. In this project we will determine how the levels of these enzymes are controlled and what is the cause of this variability between individuals. This will help us predict those individuals who are more at risk from the adverse effects of nitrogen-containing drugs and from the toxic effects of chemicals in the diet or the environment. This project will also help us develop methods to increase the levels of these protective enzymes and help reduce the effects of exposure to toxic chemicals.