Over-expression of human cytochrome P450 2J2 activates phase II biotransformation genes that influence anti-cancer drug efficacy

人细胞色素P450 2J2的过度表达激活影响抗癌药物疗效的II期生物转化基因

• 批准号: nhmrc : 1051529
• 负责人: E/Pr Peter Mackenzie
• 金额: $ 32.62万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/over-expression-human-drug-efficacy/112223
• 关键词: Over; expression; human; cytochrome; P450

Increased expression of some enzymes in human tumours contributes to anticancer drug resistance. In many tumours the fatty acid epoxygenase cytochrome P450 2J2 (CYP2J2) is over-expressed. We have found that CYP2J2 activates the expression of phase II enzymes that eliminate anticancer drugs; this is mediated by fatty acid epoxides. In this project we will define the underlying mechanisms of these effects, which may lead to novel strategies to overcome anticancer drug resistance.

人类肿瘤中某些酶的表达增加有助于抗癌药物耐药性。在许多肿瘤中，脂肪酸环氧合酶细胞色素P450 2 J2（CYP 2 J2）过度表达。我们发现CYP 2 J2激活消除抗癌药物的II相酶的表达;这是由脂肪酸环氧化物介导的。在这个项目中，我们将定义这些作用的潜在机制，这可能导致克服抗癌药物耐药性的新策略。