Regulation of drug detoxifying UDP glucuronosyltransferases

人体中的一些器官对从环境中摄取或存在于食物中的脂溶化学物质特别敏感。他们对荷尔蒙和其他小分子代谢产物也很敏感。控制这些潜在有毒化学物质的水平对于维持器官的健康至关重要。在这项工作中，我们将研究解毒酶的调节，这些解毒酶通过灭活和加速脂溶化学物质的消除来保护这些器官。

Some organs in the body are particularly sensitive to fat-soluble chemicals taken in from the environment or present in food. They are also sensitive to hormones and other small molecule products of metabolism. Controlling the levels of these potentially toxic chemicals is essential in order to maintain the health of the organ. In this work we will investigate the regulation of detoxifying enzymes that protect these organs by inactivating and hastening the elimination of fat-soluble chemicals.