Regulation of drug detoxifying UDP glucuronosyltransferases

药物解毒 UDP 葡萄糖醛酸基转移酶的调节

• 批准号: nhmrc : 1020931
• 负责人: E/Pr Peter Mackenzie
• 金额: $ 39.4万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-drug-detoxifying-udp-glucuronosyltransferases/110076
• 关键词: Regulation; drug; detoxifying; UDP; glucuronosyltransferases

Some organs in the body are particularly sensitive to fat-soluble chemicals taken in from the environment or present in food. They are also sensitive to hormones and other small molecule products of metabolism. Controlling the levels of these potentially toxic chemicals is essential in order to maintain the health of the organ. In this work we will investigate the regulation of detoxifying enzymes that protect these organs by inactivating and hastening the elimination of fat-soluble chemicals.

人体中的一些器官对从环境中摄取或存在于食物中的脂溶化学物质特别敏感。他们对荷尔蒙和其他小分子代谢产物也很敏感。控制这些潜在有毒化学物质的水平对于维持器官的健康至关重要。在这项工作中，我们将研究解毒酶的调节，这些解毒酶通过灭活和加速脂溶化学物质的消除来保护这些器官。