UDP glucuronosyltransferases as regulators of signaling pathways modulated by chemical ligands.

UDP 葡萄糖醛酸基转移酶作为化学配体调节信号通路的调节剂。

• 批准号: nhmrc : 426705
• 负责人: E/Pr Peter Mackenzie
• 金额: $ 33.37万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/udp-glucuronosyltransferases-regulators-chemical-ligands/76025
• 关键词: UDP; glucuronosyltransferases; regulators; signaling; pathways

Cells respond to their surroundings by transferring information received at the cell surface to the nucleus leading to changes in gene expression. There are many signaling pathways which transfer this informatrion to the nucleus. Some of these pathways are controlled by small molecules, usually fat-soluble chemicals. As a family of enzymes, the UDP glucuronosyltransferases (UGT) have evolved to eliminate fat-soluble chemicals, we propose that UGTs play a pivotal role in regulating the concentrations of fat-soluble chemicals involved in signaling, and thus are important in controlling gene expression. We intend to provide evidence for this novel role of UGTs in this project. This information will be used to alter the response of the cell to its environment. For example, to help protect the cell against environmental toxins, or to make a cancer cell more susceptible to a chemotherapeutic agent.

细胞通过将细胞表面接收到的信息传递给细胞核来对周围环境做出反应，从而导致基因表达的变化。有许多信号通路将这些信息传递给细胞核。其中一些途径是由小分子控制的，通常是脂溶性化学物质。UDP糖醛酸转移酶（UGT）作为一个酶家族已经进化到消除脂溶性化学物质，我们认为UGT在调节参与信号传导的脂溶性化学物质的浓度方面发挥关键作用，因此在控制基因表达方面发挥重要作用。我们打算在这个项目中为ugt的这种新作用提供证据。这些信息将被用来改变细胞对环境的反应。例如，帮助保护细胞免受环境毒素的侵害，或者使癌细胞更容易受到化疗药物的影响。