Molecular determinants of UDP glucuronosyltransferase expression in the gastrointestinal tract

胃肠道是食用化学品和口服或栓剂药物的主要入口。驻留在胃肠道中的酶在防止这些化学物质到达体内其他器官和靶组织以及保护胃肠道本身免受其影响方面具有重要作用。这些酶在胃肠道中的水平在个体之间变化很大。在这个项目中，我们将确定这些酶是如何调节的，以及是什么导致个体之间的水平存在巨大差异。这将有助于我们预测哪些人更容易受到口服药物或栓剂的不良影响以及饮食中化学物质的毒性影响。该项目还将帮助我们确定可以提高这些保护酶水平的疗法，以帮助减少接触有毒化学物质的影响。

The gastrointestinal tract is a major portal of entry for dietary chemicals and drugs taken orally or as suppositories. Enzymes resident in the gastrointestinal tract have an essential role in preventing these chemicals from reaching other organs and target tissues in the body and in protecting the gastrointestinal tract per se from their effects. The levels of these enzymes in the gastrointestinal tract varies quite extensively between individuals. In this project we will determine how these enzymes are regulated and what causes the large differences in their levels between individuals. This will help us to predict those individuals who are more at risk from the adverse effects of drugs taken orally or as suppositories and from the toxic effects of chemicals in the diet. The project will also help us identify therapies that can increase the levels of these protective enzymes to help reduce the effects of exposure to toxic chemicals .