Molecular dissection of the function of caveolae

小凹功能的分子解剖

• 批准号: nhmrc : GNT1140064
• 负责人: Prof Robert Parton
• 金额: $ 115.63万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-dissection-function-caveolae/1348279
• 关键词: Molecular; dissection; function; caveolae

The cell is the building block of life. This proposal focusses on the surface of the cell, the plasma membrane, and specialised structures called caveolae that are an abundant feature of animal cells. Altered caveolae are a feature of many human disease conditions. In this proposal we will address the function of caveolae. We will test the idea that proteins are released from caveolae into the cell when cells are stressed forming a novel signalling pathway disrupted in disease.

细胞是生命的基石。该建议的重点是细胞表面，质膜和称为小窝的专门结构，这些结构是动物细胞的丰富特征。改变的小窝是许多人类疾病的特征。在这个建议中，我们将解决的功能，窖。我们将测试的想法，蛋白质从小窝释放到细胞时，细胞受到压力，形成一个新的信号通路中断的疾病。