Structural and Functional Analysis of Plasma Membrane Microdomains in Health and Disease

健康和疾病中质膜微区的结构和功能分析

• 批准号: nhmrc : GNT1156489
• 负责人: Prof Robert Parton
• 金额: $ 88.83万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-functional-analysis-health-disease/1349213
• 关键词: Structural; Functional; Analysis; Plasma; Membrane

The cell surface encloses the cell in a protective barrier but it must also respond to signals coming from outside the cell. To accomplish this, the cell surface is made up of numerous regions each with a specialised role. This proposal aims to examine how lipids and proteins work together to make these specialised regions and aims to understand what goes wrong in diseases such as muscular dystrophy.

细胞表面将细胞包围在一个保护屏障中，但它也必须对来自细胞外部的信号做出反应。为了实现这一点，细胞表面由许多区域组成，每个区域都有专门的作用。该提案旨在研究脂质和蛋白质如何共同作用以形成这些专门区域，并旨在了解肌肉萎缩症等疾病的问题。