MOLECULAR CELL BIOLOGICAL ANALYSIS OF CAVEOLIN SECRETION

小窝蛋白分泌的分子细胞生物学分析

• 批准号: nhmrc : 631371
• 负责人: Prof Robert Parton
• 金额: $ 35.78万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-cell-biological-caveolin-secretion/95912
• 关键词: MOLECULAR; CELL; BIOLOGICAL; ANALYSIS; CAVEOLIN

Aggressive forms of prostate cancer are associated with the release of a protein, called caveolin, from the cancerous cells. Caveolin is normally embedded in the cell surface and drives the formation of microscopic pits termed caveolae. In this proposal we will investigate how caveolin is secreted with a long-term goal of preventing the secretion, or the action, of caveolin.

前列腺癌的侵袭性形式与癌细胞释放一种称为小窝蛋白的蛋白质有关。小窝蛋白通常嵌入在细胞表面，并驱动称为小窝的微观凹坑的形成。在这个建议中，我们将研究小窝蛋白是如何分泌的，长期目标是防止小窝蛋白的分泌或作用。